ArticleCytometry. Part B, Clinical cytometry2021
Use of the cell division assay to diagnose Fanconi anemia patients' hypersensitivity to mitomycin C.
Article in Cytometry. Part B, Clinical cytometry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Novel molecular assays for monitoring T cell function after HSCT in two siblings with variants inJournal of human immunity · 2026Article
- Clinical measurement of cellular DNA damage hypersensitivity in patients with DNA repair defects.Orphanet journal of rare diseases · 2022Article
- DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination.Blood science (Baltimore, Md.) · 2021Article
- Use of the cell division assay to diagnose Fanconi anemia patients' hypersensitivity to mitomycin C.Cytometry. Part B, Clinical cytometry · 2021Article
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Authors and funding
5 authors.
Funding
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Abstract
The recently reported cell division assay (CDA) was optimized to measure the relative sensitivity of cells to cytotoxic drugs in vitro. Here, we investigated the in vitro hypersensitivity of lymphocytes from Fanconi anemia (FA) patients, to cytotoxic drugs using CDA. Peripheral blood mononuclear cells (PBMC) as well as cell lines derived from FA patients were treated with two DNA interstrand crosslinking (ICL) agents, mitomycin C and cyclophosphamide. Our data indicate that the CDA detects hypersensitivity of cells from FA patients to mitomycin C. Further, cell lines derived from FA-patients were also hypersensitive to mitomycin C as well as cyclophosphamide, when assayed by the CDA. This study suggests that the CDA is a useful alternative for the diagnosis of FA patients' hypersensitivity to ICL agents.
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