ArticleGlia2020
Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach.
Article in Glia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- DisConST: Distribution-aware Contrastive Learning for Spatial Domain Identification.Genomics, proteomics & bioinformatics · 2026Article
- Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation.Frontiers in pharmacology · 2026Review
- Article
- Conditional immortalization of olfactory ensheathing cells for intelligently regulating their proliferation state.Scientific reports · 2025Article
- Olfactory Nerve Transection Transiently Activates Olfactory Ensheathing Cells in Xenopus laevis Larvae.The European journal of neuroscience · 2025Article
- Tissular chromatin-state cartography based on double-barcoded DNA arrays that capture unloaded PA-Tn5 transposase.Genome research · 2025Article
- Secretome of the Olfactory Ensheathing Cells Influences the Behavior of Neural Stem Cells.International journal of molecular sciences · 2024Article
- Olfactory immunology: the missing piece in airway and CNS defence.Nature reviews. Immunology · 2024Review
- Article
- Making a head: Neural crest and ectodermal placodes in cranial sensory development.Seminars in cell & developmental biology · 2023Review
- Identity, lineage and fates of a temporally distinct progenitor population in the embryonic olfactory epithelium.Developmental biology · 2023Article
- Spatiotemporal dynamics of the development of mouse olfactory system from prenatal to postnatal period.Frontiers in neuroanatomy · 2023Article
- Scalable and model-free detection of spatial patterns and colocalization.Genome research · 2022Article
- Retroviral lineage analysis reveals dual contribution from ectodermal placodes and neural crest cells to avian olfactory sensory and GnRH neurons.Natural sciences (Weinheim, Germany) · 2022Article
- The Immunological Roles of Olfactory Ensheathing Cells in the Treatment of Spinal Cord Injury.Frontiers in immunology · 2022Review
- Heterogeneity and Potency of Peripheral Glial Cells in Embryonic Development and Adults.Frontiers in molecular neuroscience · 2022Review
- Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Olfactory ensheathing cells (OECs) are neural crest-derived glia that ensheath bundles of olfactory axons from their peripheral origins in the olfactory epithelium to their central targets in the olfactory bulb. We took an unbiased laser microdissection and differential RNA-seq approach, validated by in situ hybridization, to identify candidate molecular mechanisms underlying mouse OEC development and differences with the neural crest-derived Schwann cells developing on other peripheral nerves. We identified 25 novel markers for developing OECs in the olfactory mucosa and/or the olfactory nerve layer surrounding the olfactory bulb, of which 15 were OEC-specific (that is, not expressed by Schwann cells). One pan-OEC-specific gene, Ptprz1, encodes a receptor-like tyrosine phosphatase that blocks oligodendrocyte differentiation. Mutant analysis suggests Ptprz1 may also act as a brake on OEC differentiation, and that its loss disrupts olfactory axon targeting. Overall, our results provide new insights into OEC development and the diversification of neural crest-derived glia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.