Evidence map›Paper›PMID 32857874›Full record

ArticleExperimental physiology2020

Peripheral chemoresponsiveness during exercise in male athletes with exercise-induced arterial hypoxaemia.

Emily A Granger, Trevor K Cooper, Susan R Hopkins, Donald C McKenzie, Paolo Dominelli

Open access · greenAbstract read
In one paragraph

Article in Experimental physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Emily A GrangerDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
Trevor K CooperSchool of Kinesiology and Division of Sports Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-3380-9493
Susan R HopkinsDepartments of Medicine and Radiology, University of California, San Diego, CA, USA.
Donald C McKenzieSchool of Kinesiology and Division of Sports Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Paolo DominelliDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0001-5575-4043
University of British Columbia · CAUniversity of Waterloo · CAUniversity of California San Diego · US

Funding

Imaging Blood Flow, Ventilation, and Density InteractionsR01HL119201 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.5M
Imaging Hypoxic Pulmonary Vasoconstriction in the Aging Lung with Proton MRIR01HL129990 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.4M
NHLBI NIH HHS R01 HL119201NHLBI NIH HHS R01 HL129990
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Do highly trained male endurance athletes who develop exercise-induced arterial hypoxaemia (EIAH) demonstrate reduced peripheral chemoresponsiveness during exercise? What is the main finding and its importance? Those with the lowest arterial saturation during exercise have a smaller ventilatory response to hypercapnia during exercise. There was no significant relationship between the hyperoxic ventilatory response and EIAH. The findings suggest that peripheral chemoresponsiveness to hypercapnia during exercise could play a role in the development of EIAH. The findings improve our understanding of the mechanisms that contribute to EIAH. ABSTRACT: Exercise-induced arterial hypoxaemia (EIAH) is characterized by a decrease in arterial oxygen tension and/or saturation during whole-body exercise, which may in part result from inadequate alveolar ventilation. However, the role of peripheral chemoresponsiveness in the development of EIAH is not well established. We hypothesized that those with the most severe EIAH would have an attenuated ventilatory response to hyperoxia and hypercapnia during exercise. To evaluate this, on separate days, we measured ventilatory sensitivity to hyperoxia and separately hypercapnia at rest and during three different exercise intensities (25, 50% of

Indexed as

ExerciseOxygen ConsumptionAthletesHumansHypercapniaHypoxiaMaleOxygenOxygencarotid chemosensorhypercapniahypoxiaventilation

Identifiers

PMID32857874
PMCPMC8232077
OpenAlexW3082765896

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.