ArticleRadiation research2020
LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy.
Article in Radiation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- TOPAS-nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution.Medical physics · 2026Article
- Ultra-high dose rate dependent modeling of plasmid DNA damage with TOPAS-nBio.Physics in medicine and biology · 2026Article
- Measurements of Hydrogen Peroxide Yields in Ultra-High-Dose-Rate vs. Conventional Radiation.Radiation research · 2026Article
- A GPU-based Monte Carlo model for water radiolysis under ultra-high dose rate irradiation: Development and validation with MPEXS2.1-DNA.Medical physics · 2025Article
- Article
- Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates.Physics in medicine and biology · 2025Article
- The role of coating layers in gold nanorods' radioenhancement: a Monte Carlo analysis.Nanoscale advances · 2025Article
- TOPAS-nBio-Reg: a regression testing system for track structure simulations in TOPAS-nBio.Physics in medicine and biology · 2025Article
- Recent updates of the MPEXS2.1-DNA Monte Carlo code for simulations of water radiolysis under ion irradiation.Scientific reports · 2025Article
- Investigating radical yield variations in FLASH and conventional proton irradiation via microscopic Monte Carlo simulations.Physics in medicine and biology · 2025Article
- Oxygen consumption measurements at ultra-high dose rate over a wide LET range.Medical physics · 2025Article
- Effect of FLASH dose-rate and oxygen concentration in the production of HPhysics in medicine and biology · 2025Article
- Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study.Physics in medicine and biology · 2024Article
- Investigating ultra-high dose rate water radiolysis using the Geant4-DNA toolkit and a Geant4 model of the Oriatron eRT6 electron linac.Scientific reports · 2024Article
- Enhancement of reactive oxygen species production by ultra-short electron pulses.Royal Society open science · 2024Article
- Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.International journal of particle therapy · 2024Review
- Dose Rate Effects from the 1950s through to the Era of FLASH.Radiation research · 2024Review
- Review
- Possible mechanisms and simulation modeling of FLASH radiotherapy.Radiological physics and technology · 2024Review
- A spatial measure-valued model for radiation-induced DNA damage kinetics and repair under protracted irradiation condition.Journal of mathematical biology · 2024Article
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6 authors.
Funding
Abstract
FLASH radiotherapy delivers a high dose (≥10 Gy) at a high rate (≥40 Gy/s). In this way, particles are delivered in pulses as short as a few nanoseconds. At that rate, intertrack reactions between chemical species produced within the same pulse may affect the heterogeneous chemistry stage of water radiolysis. This stochastic process suits the capabilities of the Monte Carlo method, which can model intertrack effects to aid in radiobiology research, including the design and interpretation of experiments. In this work, the TOPAS-nBio Monte Carlo track-structure code was expanded to allow simulations of intertrack effects in the chemical stage of water radiolysis. Simulation of the behavior of radiolytic yields over a long period of time (up to 50 s) was verified by simulating radiolysis in a Fricke dosimeter irradiated by 60Co γ rays. In addition, LET-dependent G values of protons delivered in single squared pulses of widths, 1 ns, 1 µs and 10 µs, were obtained and compared to simulations using no intertrack considerations. The Fricke simulation for the calculated G value of Fe3+ ion at 50 s was within 0.4% of the accepted value from ICRU Report 34. For LET-dependent G values at the end of the chemical stage, intertrack effects were significant at LET values below 2 keV/µm. Above 2 keV/µm the reaction kinetics remained limited locally within each track and thus, effects of intertrack reactions remained low. Therefore, when track structure simulations are used to investigate the biological damage of FLASH irradiation, these intertrack reactions should be considered. The TOPAS-nBio framework with the expansion to intertrack chemistry simulation provides a useful tool to assist in this task.
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