Evidence map›Paper›PMID 32857803›Full record

ArticlePloS one2020

Comparison of dynamic changes in stressed intravascular volume, mean systemic filling pressure and cardiovascular compliance: Pilot investigation and study protocol.

Konstantin Yastrebov, Laurencie Brunel, Zoe A Williams, Hugh S Paterson, Mariko Yata, Christopher S Burrows, Innes K Wise, Benjamin M Robinson, Paul G Bannon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Konstantin YastrebovDepartment of Intensive Care, Prince of Wales Hospital, Sydney, Australia.ORCID 0000-0002-6668-1545
Laurencie BrunelDVC Research, University of Sydney, Sydney, Australia.ORCID 0000-0003-2916-129X
Zoe A WilliamsDVC Research, University of Sydney, Sydney, Australia.ORCID 0000-0002-5139-6514
Hugh S PatersonDVC Research, University of Sydney, Sydney, Australia.ORCID 0000-0002-4593-4400
Mariko YataRoyal Prince Alfred Hospital, Sydney, Australia.ORCID 0000-0001-5697-3029
Christopher S BurrowsDVC Research, University of Sydney, Sydney, Australia.
Innes K WiseDVC Research, University of Sydney, Sydney, Australia.
Benjamin M RobinsonDVC Research, University of Sydney, Sydney, Australia.
Paul G BannonDVC Research, University of Sydney, Sydney, Australia.
The University of Sydney · AURoyal Prince Alfred Hospital · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mean systemic filling pressure (MSFP) represents an interaction between intravascular volume and global cardiovascular compliance (GCC). Intravascular volume expansion using fluid resuscitation is the most frequent intervention in intensive care and emergency medicine for patients in shock and with haemodynamic compromise. The relationship between dynamic changes in MSFP, GCC and left ventricular compliance is unknown. We conducted prospective interventional pilot study following euthanasia in post cardiotomy adult sheep, investigating the relationships between changes in MSFP induced by rapid intravascular filling with fluids, global cardiovascular compliance and left ventricular compliance. This pilot investigation suggested a robust correlation between a gradual increase in the intravascular stressed volume from 0 to 40 ml/kg and the MSFP r = 0.708 95% CI 0.435 to 0.862, making feasible future prospective interventional studies. Based on the statistical modelling from the pilot results, we expect to identify a strong correlation of 0.71 ± 0.1 (95% CI) between the MSFP and the stressed intravascular volume in a future study.

Indexed as

Blood VolumeHemodynamicsAnimalsCardiopulmonary BypassEchocardiographyFemaleHeart VentriclesModels, AnimalPilot ProjectsProspective StudiesSheepStress, PhysiologicalVentricular Function

Identifiers

PMID32857803
PMCPMC7454998
OpenAlexW3082727736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.