ArticleAnnals of clinical and translational neurology2020
White matter hyperintensities: a marker for apathy in Parkinson's disease without dementia?
Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05505019 (The Role of a Personalized Music Intervention Towards Alleviating Apathy in Parkinson's Disease), which is not on this map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of a Personalized Music Intervention Towards Alleviating Apathy in Parkinson's Disease
Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Clopidogrel use is associated with an increased prevalence of Parkinson's disease, particularly among US adults with diabetes.Clinical parkinsonism & related disorders · 2026Article
- Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Apathy progression is associated with brain atrophy and white matter damage in Parkinson's disease.Brain communications · 2025Article
- White matter hyperintensities associated with impulse control disorders in Parkinson's Disease.Scientific reports · 2023Article
- White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases.Alzheimer's research & therapy · 2023Article
- Association of Plasma Lipids with White Matter Hyperintensities in Patients with Acute Ischemic Stroke.International journal of general medicine · 2023Article
- Apathy in Parkinson's Disease: Defining the Park Apathy Subtype.Brain sciences · 2022Review
- Retinal microvascular changes in white matter hyperintensities investigated by swept source optical coherence tomography angiography.BMC ophthalmology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to assess the relationship between white matter hyperintensities (WMH) and the occurrence and progression of apathy in Parkinson's disease (PD).
methodsWe recruited patients with PD who underwent baseline evaluation, which included apathy assessment and magnetic resonance imaging (MRI) head scans. After 2.5 years of follow-up, we re-evaluated patient apathy symptoms. The severity and location of WMH were assessed with fluid-attenuated inversion recovery (FLAIR) sequences using the Fazekas visual rating scale. Logistic regression and linear regression analyses of baseline WMH characteristics were conducted to explore the potential association between apathy and WMH.
resultsA total of 141 PD patients were recruited. The apathy group had a higher proportion of male patients, advanced disease, and depression, which was coupled with a lower quality of life. Morever, higher WMH severity was significantly associated with apathy. Logistic regression analyses demonstrated that WMH severity was a risk factor for apathy. In addition, linear regression analysis also suggests that apathy severity is positively correlated with baseline WMH Fazekas scales (ϐ = 0.959, P < 0.001). Baseline WMH severity was also a risk factor for apathy progression.
interpretationWMH is associated with apathy and could be a promising marker to predict apathy progression in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.