Evidence map›Paper›PMID 32857457›Full record

SynthesisAddiction (Abingdon, England)2021

All-cause and cause-specific mortality among people with regular or problematic cocaine use: a systematic review and meta-analysis.

Amy Peacock, Lucy Thi Tran, Sarah Larney, Emily Stockings, Thomas Santo, Hayley Jones, Damian Santomauro, Louisa Degenhardt

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Addiction (Abingdon, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Amy PeacockNational Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, Australia.ORCID 0000-0002-5705-2026
Lucy Thi TranNational Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, Australia.
Sarah LarneyNational Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, Australia.ORCID 0000-0002-5602-4963
Emily StockingsNational Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, Australia.ORCID 0000-0001-5349-951X
Thomas SantoNational Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, Australia.
Hayley JonesPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-4265-2854
Damian SantomauroQueensland Centre for Mental Health Research and School of Public Health, University of Queensland, Brisbane, Australia.
Louisa DegenhardtNational Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, Australia.ORCID 0000-0002-8513-2218
UNSW Sydney · AUThe University of Queensland · AUUniversity of Bristol · GBUniversity of Tasmania · AU

Funding

Using existing data to understand and ameliorate risk in opioid agonist therapyR01DA044170 · NIDA · UNIVERSITY OF NEW SOUTH WALES · PI DEGENHARDT, LOUISA · 2017 to 2019
$641k
Medical Research Council MR/M014533/1NIDA NIH HHS R01 DA044170
6 · The paper itself

Abstract

aimsTo estimate pooled all-cause and cause-specific mortality risk for people with regular or problematic cocaine use.

methodsSystematic review and meta-analysis of prospective or retrospective cohort studies or clinical trials (n ≥30) of people with regular or problematic cocaine use with data on all-cause or cause-specific mortality. Of 2808 papers, 28 were eligible and reported on 21 cohorts, with a total 170 019 individuals. Cohorts identified based on acute care for drug poisoning or other severe health presentation were excluded. Title/abstract screening was conducted by one reviewer; a second reviewer independently checked 10% of excluded studies. Two reviewers conducted full-text screening. Data were extracted by one reviewer and checked by a second. A customized review-specific study reporting quality/risk of bias tool was used. Data on crude mortality rates (CMR) and standardized mortality ratios were extracted for both all-cause and cause-specific mortality. Standardized mortality ratios were imputed where not provided by the author using extracted data and information from the Global Burden of Disease Study 2017. Data were pooled using a random-effects model.

resultsThe pooled all-cause crude mortality rate was 1.24 per 100 person-years [95% confidence interval (CI) = 0.86, 1.78; n = 16 cohorts], but with considerable heterogeneity (I

conclusionsThere are elevated rates of mortality among people with regular or problematic cocaine use for traumatic deaths and deaths attributable to infectious disease.

Indexed as

CocaineSuicideCause of DeathHumansProspective StudiesRetrospective StudiesCocaineCardiovascularcocainehomicideinfectious diseaseinjurymortalitysuicide

Identifiers

PMID32857457
PMCPMC7914269
OpenAlexW3081318033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.