Evidence map›Paper›PMID 32857181›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2021

Antinociceptive effects of lead acetate in sciatic nerve chronic constriction injury model of peripheral neuropathy in male Wistar rats.

Bamidele Victor Owoyele, Ahmed Olalekan Bakare, Maryam Tayo Ayinla, Kehinde Ahmed Adeshina, Damilola Onietan, Saheed O Azeez

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bamidele Victor OwoyeleNeuroscience and Inflammation Unit, Department of Physiology, Faculty of Basic Medical Science, University of Ilorin, Ilorin, Kwara State, Nigeria. owoyele@unilorin.edu.ng.
Ahmed Olalekan BakareNeuroscience and Inflammation Unit, Department of Physiology, Faculty of Basic Medical Science, University of Ilorin, Ilorin, Kwara State, Nigeria.
Maryam Tayo AyinlaNeuroscience and Inflammation Unit, Department of Physiology, Faculty of Basic Medical Science, University of Ilorin, Ilorin, Kwara State, Nigeria.
Kehinde Ahmed AdeshinaNeuroscience and Inflammation Unit, Department of Physiology, Faculty of Basic Medical Science, University of Ilorin, Ilorin, Kwara State, Nigeria.
Damilola OnietanNeuroscience and Inflammation Unit, Department of Physiology, Faculty of Basic Medical Science, University of Ilorin, Ilorin, Kwara State, Nigeria.
Saheed O AzeezNeuroscience and Inflammation Unit, Department of Physiology, Faculty of Basic Medical Science, University of Ilorin, Ilorin, Kwara State, Nigeria.
University of Ilorin · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The toxicological effects of lead and its compounds have overshadowed its possible health beneficial effects. Currently, the success rate for treating neuropathic pain has been very low. This study investigated the antinociceptive effects of orally administered low dose lead acetate in sciatic nerve ligated Wistar rats. Thirty Wistar rats randomly divided into five groups were used for this study. Chronic constriction injury (CCI) was used to induce neuropathic pain in Wistar rats. Allodynic and hyperalgesic signs were investigated using von Frey filaments and hotplate, respectively. Morris water maze test was used to assess the memory functions of the rats. The study revealed that oral administration of low-dose lead acetate significantly (p < 0.05) increased pain thresholds of ligated rats. CCI enhanced memory function in Wistar rats which was significantly decreased following lead acetate administration. The findings suggest that lead acetate possesses antinociceptive effects in peripherally induced neuropathic pain model in Wistar rats.

Indexed as

AnalgesicsAnimalsBehavior, AnimalConstrictionDisease Models, AnimalHippocampusHot TemperatureHyperalgesiaKidneyLiverMaleMemoryNeuralgiaOrganometallic CompoundsRatsRats, WistarAnalgesicslead acetateOrganometallic CompoundsAllodyniaHyperalgesiaLead acetateMemoryNeuropathic painSciatic nerve

Identifiers

PMID32857181
OpenAlexW3082640039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.