Evidence map›Paper›PMID 32856853›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Urine Neutrophil Gelatinase-Associated Lipocalin a Possible Diagnostic Marker for Egyptian Hepatocellular Carcinoma Patients.

Eman Abdelsameea, Ali Nada, Nabil Omar, Saleh M Saleh, Mary Naguib, Hosam El-Din M El-Ezawy, Lamiaa Bakry, Maha Elsabaawy

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Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  4. Bioinformatic analysis of theFrontiers in cell and developmental biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eman AbdelsameeaHepatology and Gastroenterology, National Liver Institute, Menoufia University, Egypt.ORCID 0000-0002-3225-7164
Ali NadaHepatology and Gastroenterology, National Liver Institute, Menoufia University, Egypt.
Nabil OmarHepatology and Gastroenterology, National Liver Institute, Menoufia University, Egypt.
Saleh M SalehHepatology and Gastroenterology, National Liver Institute, Menoufia University, Egypt.
Mary NaguibDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Egypt.
Hosam El-Din M El-EzawyDepartment of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Egypt.
Lamiaa BakryHepatology and Gastroenterology, National Liver Institute, Menoufia University, Egypt.
Maha ElsabaawyHepatology and Gastroenterology, National Liver Institute, Menoufia University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost effective method for reducing mortality from hepatocellular carcinoma (HCC) is early diagnosis. Despite its lack of adequate sensitivity, ultrasound is considered fundamental for HCC screening.

aimto evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL) as non-invasive marker for HCC diagnosis in Egyptian patients.

methodsOne hundred and twenty patients were divided into three groups (40 patients each): patients with chronic viral hepatitis (HCV or HBV), cirrhotic patients and HCC patients and 40 healthy age and gender matched subjects were enrolled as control group. After clinical assessments, urinary NGAL was measured by enzyme-linked immunosorbent assay.

resultsOur results revealed that median level of urinary NGAL was 290, 834, 1090 and 1925 pg/ml in control, chronic hepatitis, cirrhotic and HCC groups respectively among studied groups (p<0.001). Receiver operating characteristics (ROC) analysis showed that urinary NGAL cutoff value of 1255 ng/ml could discriminate between HCC and cirrhosis. The area under curve (AUC) was 0.95 with 90% sensitivity, 87.5% specificity (p-value <0.001). In HCC group, urine NGAL level didn`t show significant correlation with Child Pugh score, MELD score or Barcelona Clinic Liver Cancer (BCLC) stage.

conclusionUrinary NGAL could be a simple, non-invasive test for diagnosis of HCC in chronic liver disease patients.<br />.

Indexed as

AdultAgedBiomarkers, TumorCarcinoma, HepatocellularCase-Control StudiesEarly Detection of CancerEgyptFemaleFollow-Up StudiesHumansLipocalin-2Liver NeoplasmsMaleMiddle AgedPrognosisROC CurveBiomarkers, TumorLCN2 protein, humanLipocalin-2hepatocellular carcinoma (HCC)Liver Cirrhosisurinary neutrophil gelatinase-associated lipocalin (NGAL)

Identifiers

PMID32856853
PMCPMC7771944

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