Evidence map›Paper›PMID 32856610›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

Early-Life Cardiorespiratory Fitness and Long-term Risk of Prostate Cancer.

Casey Crump, Pär Stattin, James D Brooks, Tanja Stocks, Jan Sundquist, Weiva Sieh, Kristina Sundquist

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Casey CrumpDepartment of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, New York. casey.crump@mssm.edu.ORCID 0000-0002-2990-1166
Pär StattinDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
James D BrooksDepartment of Urology, Stanford University School of Medicine, Stanford, California.
Tanja StocksDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Jan SundquistDepartment of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Weiva Sieh *Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-0085-1190
Kristina Sundquist *Department of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Icahn School of Medicine at Mount Sinai · USMalmö University · SELund University · SEStanford Medicine · USUppsala University · SE

Funding

Genetic Epidemiology of Ovarian and Prostate CancerK07CA143047 · NCI · STANFORD UNIVERSITY · PI SIEH, WEIVA · 2010 to 2014
$867k
NCI NIH HHS K07 CA143047
6 · The paper itself

Abstract

backgroundAdolescence is a period of rapid prostatic growth, yet is understudied for susceptibility for future risk of prostate cancer. We examined cardiorespiratory fitness (CRF) in late adolescence in relation to long-term prostate cancer risk.

methodsA population-based cohort study was conducted of all 699,125 Swedish military conscripts during 1972-1985 (97%-98% of 18-year-old men) in relation to risk of prostate cancer overall, aggressive prostate cancer, and prostate cancer mortality during 1998-2017 (ages 50-65 years). CRF was measured by maximal aerobic workload, and prostate cancer was ascertained using the National Prostate Cancer Register. Muscle strength was examined as a secondary predictor.

resultsIn 38.8 million person-years of follow-up, 10,782 (1.5%) men were diagnosed with prostate cancer. Adjusting for sociodemographic factors, height, weight, and family history of prostate cancer, high CRF was associated with a slightly increased risk of any prostate cancer [highest vs. lowest quintile: incidence rate ratio (IRR), 1.10; 95% CI, 1.03-1.19;

conclusionsHigh CRF or muscle strength in late adolescence was associated with slightly increased future risk of prostate cancer, possibly related to increased screening, but neither with risk of aggressive prostate cancer nor prostate cancer mortality. IMPACT: These findings illustrate the importance of distinguishing aggressive from indolent prostate cancer and assessing for potential detection bias.

Indexed as

AdolescentCardiorespiratory FitnessHumansMaleMiddle AgedProstatic Neoplasms

Identifiers

PMID32856610
PMCPMC7642066
OpenAlexW3074746804

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.