Evidence map›Paper›PMID 32856589›Full record

ArticleeLife2020

Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons.

Anna J Bowen, Jane Y Chen, Y Waterlily Huang, Nathan A Baertsch, Sekun Park, Richard D Palmiter

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. ParabrachialiScience · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Sex Differences in Central Amygdala Glutamate Responses to Calcitonin Gene-Related Peptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. A neural mechanism for learning from delayed postingestive feedback.bioRxiv : the preprint server for biology · 2024
    Article
  20. Activation of CGRP neurons in the parabrachial nucleus suppresses addictive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anna J BowenDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID 0000-0002-8911-2572
Jane Y ChenDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID 0000-0002-3986-8785
Y Waterlily HuangDepartment of Biochemistry, University of Washington, Seattle, United States.
Nathan A BaertschCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, United States.ORCID 0000-0003-1589-5575
Sekun ParkDepartment of Biochemistry, University of Washington, Seattle, United States.
Richard D PalmiterDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID 0000-0001-6587-0582
Howard Hughes Medical Institute · USSeattle University · US

Funding

Effect of Killing or Removing GABA from NPY/AgRP NeuronsR01DA024908 · NIDA · UNIVERSITY OF WASHINGTON · PI PALMITER, RICHARD D. · 2007 to 2021
$3.5M
Reimbursement request for attending the Meeting of the Jointly Sponsored Institutional Predoctoral Training in the Neurosciences T32 Program Directors in Baltimore, MD on 2/19/19T32NS099578 · NINDS · UNIVERSITY OF WASHINGTON · PI SULLIVAN, JANE M, WONG, RACHEL O · 2016 to 2020
$1.4M
Homeostatic Plasticity of the Respiratory Rhythm Generating NetworkK99HL145004 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BAERTSCH, NATHAN ANDREW · 2019 to 2020
$209k
NHLBI NIH HHS K99 HL145004NIDA NIH HHS R01 DA024908NINDS NIH HHS T32 NS099578
6 · The paper itself

Abstract

Parabrachial CGRP neurons receive diverse threat-related signals and contribute to multiple phases of adaptive threat responses in mice, with their inactivation attenuating both unconditioned behavioral responses to somatic pain and fear-memory formation. Because CGRP

Indexed as

AnimalsBehavior, AnimalCalcitonin Gene-Related PeptideConditioning, PsychologicalFearFemaleLearningMaleMiceNeuronsParabrachial NucleusCalcitonin Gene-Related Peptideaffectfearlearningmouseneurosciencepainparabrachialthalamus

Identifiers

PMID32856589
PMCPMC7556873
OpenAlexW3082141642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.