ArticleJournal of the American Heart Association2020
Heart Rate-Induced Myocardial Ca
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05745337 (Improving Outcomes in Atrial Fibrillation Patients Aided by Implantable Cardiac Monitor), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Outcomes in Atrial Fibrillation Patients Aided by Implantable Cardiac Monitor: Evaluation of Chronic Beta-blocker Use Versus As-needed Pharmacological Rate Control
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anti-bradycardia pacing-impact on patients with HFpEF: a systematic review.Heart failure reviews · 2024Pooled it
- Clinical Outcomes With Personalized Accelerated Physiologic Pacing in Heart Failure With Preserved Ejection Fraction: Follow-up of the myPACE Trial.JAMA cardiology · 2025Trial
- Cilostazol in patients with heart failure and preserved ejection fraction-The CLIP-HFpEF trial.ESC heart failure · 2025Trial
- Effects of Continuous Accelerated Pacing on Cardiac Structure and Function in Patients With Heart Failure With Preserved Ejection Fraction: Insights From the myPACE Randomized Clinical Trial.Journal of the American Heart Association · 2024Trial
- Novel device-based and catheter-directed therapies for heart failure with preserved ejection fraction.Cardiovascular intervention and therapeutics · 2026Review
- Real-World Treatment of Patients With Sinus Node Dysfunction and Heart Failure With Preserved Ejection Fraction.Pacing and clinical electrophysiology : PACE · 2026Article
- The clinical pathophysiology of atrial fibrillation: outstanding questions from bedside to bench and back.Physiological reviews · 2026Review
- Mechanisms of GLP-1 Receptor Agonists in HFpEF: Exploring Weight-Dependent and Independent Drivers of Therapeutic Benefit.Circulation. Heart failure · 2026Review
- A perspective on the future of heart failure research.Journal of molecular and cellular cardiology plus · 2026Article
- Comprehensive Conduction System Pacing as Antiarrhythmic Strategy in Atrial Fibrillation.JACC. Case reports · 2025Article
- Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts.Journal of visualized experiments : JoVE · 2025Article
- Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study.European heart journal · 2024Article
- Aging diastole - root cause for atrial fibrillation and heart failure with preserved ejection fraction.The journal of cardiovascular aging · 2024Article
- Personalized Accelerated Physiologic Dual Rate Pacing for Cardiac Amyloidosis.JACC. Case reports · 2024Article
- Rate-adaptive pacing in heart failure with preserved ejection fraction: Too much of a good thing?Heart rhythm O2 · 2024Article
- Accelerated physiologic pacing in patients with heart failure with preserved ejection fraction: An argument in support of therapeutic heart rate modulation.Heart rhythm O2 · 2024Article
- Advances in device-based treatment of heart failure with preserved ejection fraction: evidence from clinical trials.ESC heart failure · 2024Review
- Rationale and design of the PACE HFpEF trial: Physiologic accelerated pacing as a holistic treatment of heart failure with preserved ejection fraction.Heart rhythm O2 · 2024Article
- Personalized accelerated physiologic pacing.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Lower heart rates and beta-blockers are associated with new-onset atrial fibrillation.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Background Increases in heart rate are thought to result in incomplete left ventricular (LV) relaxation and elevated filling pressures in patients with heart failure with preserved ejection fraction (HFpEF). Experimental studies in isolated human myocardium have suggested that incomplete relaxation is a result of cellular Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.