Evidence map›Paper›PMID 32856432›Full record

ArticleStem cells translational medicine2021

Regen med therapeutic opportunities for fighting COVID-19.

Anthony Atala, Alicia Henn, Martha Lundberg, Taby Ahsan, Jordan Greenberg, Jeff Krukin, Steven Lynum, Cat Lutz, Kyle Cetrulo, Mohammad Albanna and 3 more

Abstract read
In one paragraph

Article in Stem cells translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. COVID-19 and the role of stem cells.Regenerative therapy · 2021
    Review
  7. Article
  8. Review
  9. Recent Advances of COVID-19 Modeling Based on Regenerative Medicine.Frontiers in cell and developmental biology · 2021
    Review
  10. Regen med therapeutic opportunities for fighting COVID-19.Stem cells translational medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anthony AtalaWake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA.
Alicia HennBiospherix, Lacona, New York, USA.
Martha LundbergNational Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, USA.
Taby AhsanRoosterBio, Frederick, Maryland, USA.
Jordan GreenbergOrganabio, Miami, Florida, USA.ORCID 0000-0002-4138-2477
Jeff KrukinOrbital Transports, Chicago, Illinois, USA.
Steven LynumPHC Group, Livingston, New Jersey, USA.
Cat LutzJackson Labs, Mount Desert Island, Maine, USA.
Kyle CetruloInternational Perinatal Stem Cell Society, Inc., Westport, Connecticut, USA.
Mohammad AlbannaHumabiologics, Inc., Phoenix, Arizona, USA.
Taciana PereiraAllevi, Philadelphia, Pennsylvania, USA.
Shannon EakerCytiva, Marlborough, Massachusetts, USA.
Joshua HunsbergerRegenerative Medicine Manufacturing Society, Winston-Salem, North Carolina, USA.ORCID 0000-0002-8683-6129

Funding

NIH HHSU.S. Department of Health and Human Services
6 · The paper itself

Abstract

This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID-19. This article addresses why SARS-CoV-2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID-19. We describe animal models that depict the mechanism of action for COVID-19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying at-risk patients. This article critically evaluates some of the promising regenerative medicine-based therapies for treating COVID-19 and presents some of the collective technologies and resources that the scientific community currently has available to confront this pandemic.

Indexed as

AnimalsCOVID-19HumansRegenerative MedicineSARS-CoV-2animal modelsCOVID-19mesenchymal stromal/stem cellsorganoidsregenerative medicineSARS-CoV-2

Identifiers

PMID32856432
PMCPMC7461298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.