ArticleMicrobiologyOpen2020
Microbial interaction between the succinate-utilizing bacterium Phascolarctobacterium faecium and the gut commensal Bacteroides thetaiotaomicron.
Article in MicrobiologyOpen, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 109 citations in OpenAlex.
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- Effectiveness of Multistrain Probiotic Formulation on Common Infectious Disease Symptoms and Gut Microbiota Modulation in Flu-Vaccinated Healthy Elderly Subjects.BioMed research international · 2022Trial
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- Advances in Exercise-Mediated Regulation of the Gut Microbiota via the Muscle-Gut Axis: Implications for Tumor Immunity and Treatment Responses.Metabolites · 2026Review
- Impact of Combined Botanical Functional Ingredients on the Canine Gut Microbiome.Veterinary sciences · 2026Article
- Dose-dependent effects of dietary Maotai distillers' grains on growth performance and selected intestinal responses in Pekin ducks.Poultry science · 2026Article
- Vegetable trimming pellets in laying hen diets drive cecal remodeling and dose-dependent plasma-egg metabolomic dissociation.Poultry science · 2026Article
- Laminaria extract reshapes the gut microbiota and TCA cycle-centered metabolic profiles associated with immune modulation in Hu lambs.BMC veterinary research · 2026Article
- Dietary potassium diformate improves slaughter performance, systemic metabolic homeostasis, and intestinal health without compromising growth performance in Qingyuan Partridge chickens.Poultry science · 2026Article
- Fusobacterium varium Exacerbates Neutrophil-driven Intestinal Inflammation Associated with Succinate-SUCNR1-NF-κB Signaling.Inflammation · 2026Article
- Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice.Nature microbiology · 2026Article
- A case-series of oral acetate supplementation for gut microbiota alteration and metabolic improvement in patients with affective disorders on psychotropics.Translational psychiatry · 2026Article
- Microbiota-derived propionate suppresses Salmonella virulence gene expression via LuxS quorum sensing.Microbiome · 2026Article
- Safety and Tolerability of the Gut BacteriumNutrients · 2026Article
- Gut microbiome dysregulation is associated with segmental glomerulosclerosis in IgA nephropathy: insights from Oxford classification-based microbiome profiling.Frontiers in cellular and infection microbiology · 2026Article
- A molecular inventory of the faecal microbiomes of 23 marsupial species.Microbial genomics · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large variety of microbes are present in the human gut, some of which are considered to interact with each other. Most of these interactions involve bacterial metabolites. Phascolarctobacterium faecium hardly uses carbohydrates for growth and instead uses succinate as a substrate. This study investigated the growth behavior of the co-culture of the succinate-specific utilizer P. faecium and the succinogenic gut commensal Bacteroides thetaiotaomicron. Succinate production by B. thetaiotaomicron supported the growth of P. faecium and concomitant propionate production via the succinate pathway. The succinate produced was completely converted to propionate. This result was comparable with the monoculture of P. faecium in the medium supplemented with 1% (w/v) succinate. We analyzed the transcriptional response (RNA-Seq) between the mono- and co-culture of P. faecium and B. thetaiotaomicron. Comparison of the expression levels of genes of P. faecium between the mono- and co-cultured conditions highlighted that the genes putatively involved in the transportation of succinate were notably expressed under the co-cultured conditions. Differential expression analysis showed that the presence of P. faecium induced changes in the B. thetaiotaomicron transcriptional pattern, for example, expression changes in the genes for vitamin B
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