ArticleMacromolecular bioscience2020
Rheological Properties of Coordinated Physical Gelation and Chemical Crosslinking in Gelatin Methacryloyl (GelMA) Hydrogels.
Article in Macromolecular bioscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- From Gelatin to GelMA: Versatility, Challenges, and Biomedical Applications of GelMA Hydrogels.Gels (Basel, Switzerland) · 2026Review
- Gelatin Hydrogel Crosslinking: From Molecular Design to Functional Soft Materials.Gels (Basel, Switzerland) · 2026Review
- Structural and Antimicrobial Characterization of Porcine and Fish Gelatin Hydrogels Photochemically Crosslinked with Menadione Sodium Bisulfite.Gels (Basel, Switzerland) · 2026Article
- Designing Tunable GelMA Hydrogels by Integrating Mammalian and Non-Mammalian Gelatins.Gels (Basel, Switzerland) · 2026Article
- Solid-phase synthesis of high affinity interleukin-6 binders made of gelatin-methacryloyl via a molecular imprinting technique.Materials today. Bio · 2026Article
- Modern Drug Delivery Platforms Based on Photocrosslinkable Hydrogels (PCHs) in Dentistry: From Material Characteristics to Clinical Applications-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Comprehensive Characterization of Solution-Cast Polycaprolactone/MXene/Gelatin Composite Films for Biomedical Applications.Biopolymers · 2026Article
- Routine Direct Quantification of Methacrylic Groups per Gelatin Unit in Gelatin Methacryloyl Using Ultraviolet Spectroscopy.Biomacromolecules · 2026Article
- Preparation, Characterization, and Application ofFoods (Basel, Switzerland) · 2026Article
- 3D Printing with Tragacanth-Gum-Based Bioinks: A New Frontier in Bioprinting Materials.Gels (Basel, Switzerland) · 2026Review
- Tailoring composite hydrogel performanceBiomaterials science · 2026Article
- Fabrication of Patterned Composite Microneedles via Inkjet Printing for Enhanced Drug Delivery.Advanced healthcare materials · 2026Article
- Xeno-Free Biocompatible Peptide-Based Bioinks Reinforced with Cellulose Nanofibers for 3D Printing.Advanced healthcare materials · 2026Article
- Bioinks in systems biology: integrating biomaterial design with cellular network modelling for predictive biofabrication.Frontiers in bioengineering and biotechnology · 2026Review
- Mechanical Tuning of the Cell Microenvironment Using a Biomimetic Hydrogel System for Articular Cartilage Tissue Engineering.Journal of tissue engineering and regenerative medicine · 2026Article
- Shape-fit 3D printed mineralized membrane for guided bone regeneration in long bone defects.Journal of nanobiotechnology · 2025Article
- Optimizing Gelatin Methacryloyl for Craniofacial Muscle Regeneration: Material Design and Application.Gels (Basel, Switzerland) · 2025Article
- Conjugation of Proangiogenic Peptide to Enhance a Soft Tissue Bioink.Journal of biomedical materials research. Part A · 2025Article
- A Biocompatible and Self-Healable 3D-Printed Bidirectional Hydrogel Actuator with Needle Injectability.ACS applied materials & interfaces · 2025Article
- Thermally Cured Gelatin-Methacryloyl Hydrogels Form Mechanically Modulating Platforms for Cell Studies.Biomacromolecules · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Synthetically modified proteins, such as gelatin methacryloyl (GelMA), are growing in popularity for bioprinting and biofabrication. GelMA is a photocurable macromer that can rapidly form hydrogels, while also presenting bioactive peptide sequences for cellular adhesion and proliferation. The mechanical properties of GelMA are highly tunable by modifying the degree of substitution via synthesis conditions, though the effects of source material and thermal gelation have not been comprehensively characterized for lower concentration gels. Herein, the effects of animal source and processing sequence are investigated on scaffold mechanical properties. Hydrogels of 4-6 wt% are characterized. Depending on the temperature at crosslinking, the storage moduli for GelMA derived from pigs, cows, and cold-water fish range from 723 to 7340 Pa, 516 to 3484 Pa, and 294 to 464 Pa, respectively. The maximum storage moduli are achieved only by coordinated physical gelation and chemical crosslinking. In this method, the classic thermo-reversible gelation of gelatin occurs when GelMA is cooled below a thermal transition temperature, which is subsequently "locked in" by chemical crosslinking via photocuring. The effects of coordinated physical gelation and chemical crosslinking are demonstrated by precise photopatterning of cell-laden microstructures, inducing different cellular behavior depending on the selected mechanical properties of GelMA.
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