Evidence map›Paper›PMID 32856213›Full record

GuidelineSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune checkpoint inhibitor endocrinopathies and the role of advanced practice providers in the management of immune-mediated toxicities.

Tim Cooksley, Monica Girotra, Pamela Ginex, Ruth Ann Gordon, Ronald Anderson, Ada Blidner, Jennifer Choi, Michael Dougan, Ilya Glezerman, Dipti Gupta and 4 more

Abstract readHistorical ArticlePractice GuidelineReview
PubMed Publisher
In one paragraph

Guideline in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Preexisting autoimmune disease is a risk factor for immune-related adverse events: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  3. Review
  4. Article
  5. Review
  6. Knowledge and quality of life in cancer patients receiving immunotherapy for the first time. A cross-sectional study about being informed.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Adrenal Failure: An Evidence-Based Diagnostic Approach.Diagnostics (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 4 countries.

Tim CooksleyThe Christie and Manchester University Foundation Trust, Manchester, UK.
Monica GirotraDepartment of Medicine, Endocrine Division, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Pamela GinexOncology Nursing Society, Pittsburgh, PA, USA.
Ruth Ann GordonClinical Trials, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ronald AndersonDepartment of Immunology, Faculty of Health Sciences, University or Pretoria, Corner Doctor Savage Road and Bophelo Road, Pretoria, 0002, South Africa.
Ada BlidnerLaboratory of Immunopathology, Institute of Biology and Experimental Medicine-CONICET, Buenos Aires, Argentina.
Jennifer ChoiDivision of Oncodermatology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael DouganMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ilya GlezermanRenal Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Dipti GuptaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Douglas JohnsonDepartment of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA.
Vickie R ShannonDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Maria Suarez-AlmazorSection of Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bernardo L RapoportDepartment of Immunology, Faculty of Health Sciences, University or Pretoria, Corner Doctor Savage Road and Bophelo Road, Pretoria, 0002, South Africa. bernardo.rapoport@up.ac.za.ORCID http://orcid.org/0000-0001-7610-3653
Memorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARHarvard University · USNorthwestern University · USOncology Nursing Society · USThe Medical Oncology Centre of Rosebank · ZAUniversity of Manchester · GBUniversity of Pretoria · ZAVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have emerged as the newest pillar of cancer treatment, transforming outcomes in melanoma and showing benefit in a range of malignancies. Immune-mediated toxicities, stemming from increased activity within the T cell lineage, range from asymptomatic or mild complications to those that are fulminant and potentially fatal. Immune-mediated endocrinopathies include hypophysitis, thyroiditis, and insulin-dependent diabetes mellitus. These presentations, which may be vague and non-specific, can be life-threatening if not diagnosed and treated appropriately. This review considers the work-up and management of immune-mediated endocrinopathies and also considers the role of advanced practice practitioners in the management of immune-mediated toxicities. These state-of-the-art MASCC recommendations represent a comprehensive overview of the management and clinical work-up in those in whom the diagnosis should be considered.

Indexed as

Physician's RoleCTLA-4 AntigenDrug-Related Side Effects and Adverse ReactionsEndocrine System DiseasesHistory, 21st CenturyHumansImmune Checkpoint InhibitorsImmunologic FactorsImmunotherapyInternational AgenciesMedical OncologyNeoplasmsPalliative CarePalliative MedicineProgrammed Cell Death 1 ReceptorSeverity of Illness IndexCTLA-4 AntigenCTLA4 protein, humanImmune Checkpoint InhibitorsImmunologic FactorsProgrammed Cell Death 1 ReceptorAPPs (advanced practice providers)CorticosteroidsDiabetesHyperglycemiaHypophysitisThyroiditis

Identifiers

PMID32856213
OpenAlexW3081837916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.