Evidence map›Paper›PMID 32856212›Full record

GuidelineSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-mediated cardiovascular, rheumatic, and renal toxicities from checkpoint inhibitors.

Maria E Suarez-Almazor, Xerxes Pundole, Noha Abdel-Wahab, Douglas B Johnson, Dipti Gupta, Ilya Glezerman, Tim Cooksley, Ronald Anderson, Ada Blidner, Jennifer Choi and 5 more

Abstract readHistorical ArticlePractice GuidelineReview
PubMed Publisher
In one paragraph

Guideline in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Improved outcomes with early immunosuppression in patients with immune-checkpoint inhibitor induced myasthenia gravis, myocarditis and myositis: a case series.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Review
  10. Review
  11. Renal Toxicity.Advances in experimental medicine and biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maria E Suarez-AlmazorSections of Health Services Research and Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xerxes PundoleSection of Health Services Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Noha Abdel-WahabSection of Health Services Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Douglas B JohnsonDepartment of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA.
Dipti GuptaCardiology Division, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ilya GlezermanRenal Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Tim CooksleyThe Christie, Manchester, UK.
Ronald AndersonFaculty of Health Sciences, Department of Immunology, University or Pretoria, Corner Doctor Savage Road and Bophelo Road, Pretoria, 0002, South Africa.
Ada BlidnerLaboratory of Immunopathology, Institute of Biology and Experimental Medicine-CONICET, Buenos Aires, Argentina.
Jennifer ChoiDivision of Oncodermatology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael DouganMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Pamela GinexOncology Nursing Society, Pittsburgh, PA, USA.
Monica GirotraEndocrine Division, Department of Medicine, Weill Cornell Medical College (MG, AF), New York, NY, USA.
Vickie R ShannonDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bernardo L RapoportFaculty of Health Sciences, Department of Immunology, University or Pretoria, Corner Doctor Savage Road and Bophelo Road, Pretoria, 0002, South Africa. bernardo.rapoport@up.ac.za.ORCID http://orcid.org/0000-0001-7610-3653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have emerged as the newest pillar of cancer treatment. Immune-mediated toxicities, stemming from increased activity within the T cell lineage, range from asymptomatic or mild complications to those that are fulminant and potentially fatal. Although they are of variable occurrence, cardiovascular, rheumatic, and renal immune-mediated toxicities are among the most serious of these adverse events. We present MASCC recommendations with respect to the workup and management of cardiovascular, rheumatic, and renal immune-mediated toxicities with a focus on presentations that require treatment with immunomodulating agents.

Indexed as

Cardiovascular DiseasesCTLA-4 AntigenDrug-Related Side Effects and Adverse ReactionsHistory, 21st CenturyHumansImmune Checkpoint InhibitorsImmunologic FactorsImmunotherapyInternational AgenciesKidney DiseasesNeoplasmsPalliative CarePalliative MedicineProgrammed Cell Death 1 ReceptorRheumatic DiseasesSeverity of Illness IndexCTLA-4 AntigenCTLA4 protein, humanImmune Checkpoint InhibitorsImmunologic FactorsProgrammed Cell Death 1 ReceptorArthralgiaArthritisCardiomyopathyCorticosteroidsImmunomodulation agentsMyocarditisMyositisOther immunosuppressive agentsPolymyalgia

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.