Evidence map›Paper›PMID 32856009›Full record

ArticleJournal of the Endocrine Society2020

Diagnostic Value of Molecular Testing in Sonographically Suspicious Thyroid Nodules.

Maxwell M Wang, Katrina Beckett, Michael Douek, Rinat Masamed, Maitraya Patel, Chi-Hong Tseng, Michael W Yeh, Angela M Leung, Masha J Livhits

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Maxwell M WangDavid Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
Katrina BeckettDepartment of Radiology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
Michael DouekDepartment of Radiology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
Rinat MasamedDepartment of Radiology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
Maitraya PatelDepartment of Radiology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.ORCID 0000-0003-3329-3615
Chi-Hong TsengDepartment of Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
Michael W YehSection of Endocrine Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
Angela M LeungDivision of Endocrinology, Diabetes, and Metabolism, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.ORCID 0000-0001-8935-9332
Masha J LivhitsSection of Endocrine Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.ORCID 0000-0002-8436-392X
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMolecular testing can refine the diagnosis for the 20% of thyroid fine-needle aspiration biopsies that have indeterminate cytology. We assessed the diagnostic accuracy of molecular testing based on ultrasound risk classification.

methodsThis retrospective cohort study analyzed all thyroid nodules with indeterminate cytology at an academic US medical center (2012-2016). All indeterminate nodules underwent reflexive molecular testing with the Afirma Gene Expression Classifier (GEC). Radiologists performed blinded reviews to categorize each nodule according to the American Thyroid Association (ATA) ultrasound classification and the American College of Radiology Thyroid Imaging, Reporting and Data System. GEC results and diagnostic performance were compared across ultrasound risk categories.

resultsOf 297 nodules, histopathology confirmed malignancy in 65 (22%). Nodules by ATA classification were 8% high suspicion, 44% intermediate, and 48% low/very low suspicion. A suspicious GEC result was more likely in ATA high-suspicion nodules (81%) than in nodules of all other ATA categories (57%;

conclusionThe PPV of molecular testing remained consistent across ultrasound risk categories. However, a suspicious GEC result was very likely in ATA high-suspicion nodules and did not improve specificity in this sonographic category.

Indexed as

ACR TI-RADSATAmolecular testingnodulethyroidultrasound

Identifiers

PMID32856009
PMCPMC7442277
OpenAlexW3036576761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.