Evidence map›Paper›PMID 32855969›Full record

ArticleBioMed research international2020

Transcriptomics Study to Determine the Molecular Mechanism by which sIL-13R

Xin Wang, Jianshi Tan, Junhao Sun, Pengzhong Fang, Jinlei Chen, Wen Yuan, Huajiang Chen, Yang Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The Proteolysis of ECM in Intervertebral Disc Degeneration.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xin WangDepartment of Orthopedics, First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China 730000.ORCID https://orcid.org/0000-0002-0728-6166
Jianshi TanDepartment of Orthopedics, First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China 730000.
Junhao SunDepartment of Orthopedics, First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China 730000.
Pengzhong FangDepartment of Orthopedics, First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China 730000.
Jinlei ChenDepartment of Orthopedics, First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China 730000.
Wen YuanChangzheng Orthopedics Hospital, Second Military Medical University, Shanghai, China 200003.
Huajiang ChenChangzheng Orthopedics Hospital, Second Military Medical University, Shanghai, China 200003.
Yang LiuChangzheng Orthopedics Hospital, Second Military Medical University, Shanghai, China 200003.ORCID https://orcid.org/0000-0002-8827-7279
First Hospital of Lanzhou University · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntervertebral disc degeneration is related to tissue fibrosis. ADAMTS can degrade the important components of the ECM during the process of intervertebral disc degeneration, ultimately resulting in the loss of intervertebral disc function. sIL-13R

objectiveTo determine the mechanism by which sIL-13R

methodsA rat model of caudal intervertebral disc degeneration was established, and Sirius red staining was used to observe the pathological changes in the caudal intervertebral disc. Transcriptome sequencing was employed to assess the gene expression profiles of the intervertebral disc tissues in the model group and the sIL-13R

resultsSirius red staining showed that in the model group, the annulus fibrosus was disordered, the number of breaks increased, and the type I collagen protein levels increased, whereas in the sIL-13R

conclusion

Indexed as

AnimalsCollagen Type ICollagen Type IIGene Expression ProfilingImmunoglobulin Fc FragmentsInterleukin-13 Receptor alpha2 SubunitIntervertebral DiscIntervertebral Disc DegenerationRats, Sprague-DawleyReal-Time Polymerase Chain ReactionRecombinant ProteinsTissue Inhibitor of Metalloproteinase-1Collagen Type ICollagen Type IIImmunoglobulin Fc FragmentsInterleukin-13 Receptor alpha2 SubunitRecombinant ProteinsTissue Inhibitor of Metalloproteinase-1

Identifiers

PMID32855969
PMCPMC7443219
OpenAlexW3049458018

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.