Evidence map›Paper›PMID 32855891›Full record

ArticleTranslational vision science & technology2020

Comparison of SDOCT Scan Types for Grading Disorganization of Retinal Inner Layers and Other Morphologic Features of Diabetic Macular Edema.

Konstantina Sampani, Marwan Abdulaal, Timothy Peiris, Michael M Lin, Cloyd Pitoc, Migil Ledesma, Jan Lammer, Paolo S Silva, Lloyd Paul Aiello, Jennifer K Sun

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Indicators of Visual Prognosis in Diabetic Macular Oedema.Journal of personalized medicine · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Konstantina SampaniBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Marwan AbdulaalDepartment of Ophthalmology, Case Western Reserve University, Cleveland, OH, USA.
Timothy PeirisDepartment of Ophthalmology, Zucker School of Medicine at Hofstra/Northwell, East Garden City, NY, USA.
Michael M LinDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Cloyd PitocPhilippine Eye Research Institute, University of the Philippines, Manila, Philippines.
Migil LedesmaPhilippine Eye Research Institute, University of the Philippines, Manila, Philippines.
Jan LammerDepartment of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Paolo S SilvaBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Lloyd Paul AielloBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Jennifer K SunBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Harvard University · USUniversity of the Philippines Manila · PHCase Western Reserve University · USHofstra University · USJoslin Diabetes Center · USMassachusetts Eye and Ear Infirmary · USMedical University of Vienna · AT

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Predicting Outcomes & Anti-VEGF Response in Diabetic Eyes by Adaptive Optics SLOR01EY024702 · NEI · JOSLIN DIABETES CENTER · PI SUN, JENNIFER KATHERINE · 2014 to 2018
$1.7M
NEI NIH HHS R01 EY024702NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

Purpose: To assess grading reproducibility of disorganization of the retinal inner layers (DRIL) and other morphologic features of diabetic macular edema (DME) across spectral domain optical coherence tomography (SDOCT) instruments and scan types. Methods: A cross-sectional study enrolled participants with current or recent center-involved DME. In group A (27 eyes), we obtained two Cirrus scans (512 × 128 macular cube [Cube] and high-definition five-line raster [HD 5-Line]) and two Spectralis scans (high-resolution [HR] and high-speed [HS]). In group B, 26 eyes underwent HR scans and Optovue AngioVue (OP) 3 × 3-mm scans. All scans were graded for type and extent of DRIL, intraretinal cysts, cone outer segment tip visibility, and subretinal fluid (SRF). Results: In the total cohort, mean central subfield thickness was 342.9 ± 83.4 µm. Intraclass correlations were high for DRIL extent across the four different imaging settings (HR vs. HS, Conclusions: Our data suggest that the reproducibility for SDOCT parameters of DRIL and intraretinal cysts was high across all five SDOCT scan types; thus, evaluation of DRIL is feasible using multiple SDOCT models in eyes with DME. Translational Relevance: DME morphological changes can be evaluated on multiple SDOCT devices with good reproducibility, allowing clinicians and researchers flexibility in DME assessment for clinical care and research.

Indexed as

Diabetes MellitusDiabetic RetinopathyMacular EdemaCross-Sectional StudiesFluorescein AngiographyFollow-Up StudiesHumansReproducibility of ResultsRetrospective StudiesTomography, Optical CoherenceVisual Acuitydiabetic macular edemadiabetic retinopathydisorganization of retinal inner layersDRILSDOCT

Identifiers

PMID32855891
PMCPMC7422902
OpenAlexW3046878296

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.