ArticleTranslational vision science & technology2020
Expression Profiles of Inflammatory Cytokines in the Aqueous Humor of Children after Congenital Cataract Extraction.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Occlusion Break Surge and Anterior Chamber Stability in the Intraocular Environment of Modern Phacoemulsification: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery.Investigative ophthalmology & visual science · 2025Article
- Changes in aqueous humor cytokines and metabolomics in contralateral eye after unilateral cataract surgery.BMC ophthalmology · 2025Article
- Impact of residual peripheral anterior synechiae extent on surgical outcomes after viscogonioplasty in primary angle-closure disease.International journal of ophthalmology · 2025Article
- Exploring anterion capsular contraction syndrome in cataract surgery: insights into pathogenesis, clinical course, influencing factors, and intervention approaches.Frontiers in medicine · 2024Review
- Cytokines in aqueous humor of patients with congenital cataract during delayed sequential bilateral cataract surgery.BMC ophthalmology · 2023Article
- Retrospective study of postoperative intraocular pressure and complications in phacoemulsification combined with endoscopic cyclophotocoagulation and phacoemulsification alone in dogs.Journal of veterinary science · 2023Article
- Single vesicle analysis of aqueous humor in pediatric ocular diseases reveals eye specific CD63-dominant subpopulations.Journal of extracellular biology · 2022Article
- Glaucoma and risk factors three years after congenital cataract surgery.BMC ophthalmology · 2022Article
- Morphological changes in the iridocorneal angle and their relationship with intraocular pressure after infantile cataract surgery.International journal of ophthalmology · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the change in cytokine microenvironment of the aqueous humor (AH) after surgery in children with congenital or developmental cataracts. Methods: AH samples were obtained from 59 eyes diagnosed with a congenital or developmental cataract. Thirty-three of these eyes were aphakic following previous cataract surgery and were scheduled for secondary intraocular lens (IOL) implantation. Additionally, AH samples from 26 eyes that had not undergone surgery were taken. AH samples were then analyzed for 16 different inflammatory immune mediators using multiplex bead immunoassays and enzyme-linked immunosorbent assay (ELISA). Results: The mean interval between secondary IOL implantation and original cataract surgery was 24.85 months (range, 9-60 months). Levels of IL-6, IP-10 (CXCL10), MCP-1 (CCL2), and IL-2 were significantly elevated in the AH of eyes after surgery compared to eyes that did not undergo surgery ( Conclusions: To our knowledge, this is the first study to report significantly increased proinflammatory cytokine levels in the AH after congenital cataract extraction in children. Our study also suggests that this proinflammatory state may be maintained for a prolonged period of time. Overall, these results give us insight into the relationship between the inflammatory cytokine microenvironment of the aqueous humor and potential long-term complications following congenital cataract surgery. Translational Relevance: The inflammatory cytokine microenvironment of the aqueous humor might help explain potential long-term complications after surgery in patients with congenital or developmental cataracts.
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