Evidence map›Paper›PMID 32855422›Full record

ReviewNature reviews. Disease primers2020

ANCA-associated vasculitis.

A Richard Kitching, Hans-Joachim Anders, Neil Basu, Elisabeth Brouwer, Jennifer Gordon, David R Jayne, Joyce Kullman, Paul A Lyons, Peter A Merkel, Caroline O S Savage and 2 more

Registry-linked trialOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06590545 (Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis), which is not on this map. Cited by 523 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
523citing papers in PubMed, 3 pooled it
55.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06590545 phase1 / phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis: a Two-stage Interventional, Prospective, Open-label, Phase I/II Trial in Patients With Active, Treatment Refractory, ANCA-IgG-positive Vasculitis

TypeinterventionalSponsorDavid SimonRan2025 to 2027Enrolled8ConditionsANCA-IgG-positive ANCA Associated VasculitisArmsKYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy
3 · Its place in the literature

Who cites it

523 citing papers in PubMed, 3 syntheses or guidelines pooled it, 851 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. The theory of the inflammatory ecosystem.Science China. Life sciences · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Recognition of ear, nose and throat involvement in patients with ANCA-associated vasculitis: from in-depth interviews to insights for the future.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

463 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 6 countries.

A Richard KitchingCentre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia. richard.kitching@monash.edu.
Hans-Joachim AndersRenal Division, Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians University, Munich, Germany.
Neil BasuInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Elisabeth BrouwerVasculitis Expertise Centre Groningen, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
Jennifer GordonDepartment of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA.
David R JayneDepartment of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Joyce KullmanVasculitis Foundation, Kansas City, MO, USA.
Paul A LyonsDepartment of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Peter A MerkelDivision of Rheumatology, Department of Medicine and Division of Clinical Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
Caroline O S SavageInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Ulrich SpecksDivision of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Renate KainDepartment of Pathology, Medical University Vienna, Vienna, Austria.
University of Cambridge · GBLudwig-Maximilians-Universität München · DEMayo Clinic · USMedical University of Vienna · ATMonash University · AUTemple University · USUniversity of Birmingham · GBUniversity of Glasgow · GBUniversity of Groningen · NLUniversity of Pennsylvania · USVasculitis Foundation · US

Funding

British Heart Foundation PG/13/64/30435Medical Research Council MR/L019027/1Versus Arthritis 20593
6 · The paper itself

Abstract

The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of disorders involving severe, systemic, small-vessel vasculitis and are characterized by the development of autoantibodies to the neutrophil proteins leukocyte proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA). The three AAV subgroups, namely granulomatosis with polyangiitis (GPA), microscopic polyangiitis and eosinophilic GPA (EGPA), are defined according to clinical features. However, genetic and other clinical findings suggest that these clinical syndromes may be better classified as PR3-positive AAV (PR3-AAV), MPO-positive AAV (MPO-AAV) and, for EGPA, by the presence or absence of ANCA (ANCA

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisDiagnostic ImagingHumansImmunosuppressive AgentsMyeloblastinPeroxidasePrognosisRisk FactorsImmunosuppressive AgentsMyeloblastinPeroxidase

Identifiers

PMID32855422
OpenAlexW137802152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.