ArticleNature communications2020
Cell-surface receptors enable perception of extracellular cytokinins.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 71 citations in OpenAlex.
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Natural variation of CsUGT71A60 determines growth and cold tolerance via regulating cytokinin glycosylation in Camellia sinensis.Plant biotechnology journal · 2025Article
- Type-A and -C response regulator genes positively impact rice plant height and panicle architecture.Plant cell reports · 2025Article
- Five unaddressed questions about cytokinin biosynthesis.Journal of experimental botany · 2025Review
- Structural basis of cytokinin transport by the Arabidopsis AZG2.Nature communications · 2025Article
- Multi-omics analysis of organ-specific hormone distribution and molecular regulatory mechanisms inFrontiers in plant science · 2025Article
- Hormonal regulation and crosstalk during early endosperm and seed coat development.Plant reproduction · 2024Review
- The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development.Plant physiology · 2024Article
- Primary multistep phosphorelay activation comprises both cytokinin and abiotic stress responses: insights from comparative analysis of Brassica type-A response regulators.Journal of experimental botany · 2024Article
- SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia.Nature communications · 2024Article
- Spatially distributed cytokinins: Metabolism, signaling, and transport.Plant communications · 2024Review
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- Dissecting the Roles of the Cytokinin Signaling Network: The Case of De Novo Shoot Apical Meristem Formation.Biomolecules · 2024Review
- A Model of the Full-Length Cytokinin Receptor: New Insights and Prospects.International journal of molecular sciences · 2023Article
- A cell wall-localized cytokinin/purine riboside nucleosidase is involved in apoplastic cytokinin metabolism inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multi-Knock-a multi-targeted genome-scale CRISPR toolbox to overcome functional redundancy in plants.Nature plants · 2023Article
- The origin and early evolution of cytokinin signaling.Frontiers in plant science · 2023Review
- Fourteen Stations of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
- ADA2b and GCN5 Affect Cytokinin Signaling by Modulating Histone Acetylation and Gene Expression during Root Growth ofPlants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 5 countries.
Funding
Abstract
Cytokinins are mobile multifunctional plant hormones with roles in development and stress resilience. Although their Histidine Kinase receptors are substantially localised to the endoplasmic reticulum, cellular sites of cytokinin perception and importance of spatially heterogeneous cytokinin distribution continue to be debated. Here we show that cytokinin perception by plasma membrane receptors is an effective additional path for cytokinin response. Readout from a Two Component Signalling cytokinin-specific reporter (TCSn::GFP) closely matches intracellular cytokinin content in roots, yet we also find cytokinins in extracellular fluid, potentially enabling action at the cell surface. Cytokinins covalently linked to beads that could not pass the plasma membrane increased expression of both TCSn::GFP and Cytokinin Response Factors. Super-resolution microscopy of GFP-labelled receptors and diminished TCSn::GFP response to immobilised cytokinins in cytokinin receptor mutants, further indicate that receptors can function at the cell surface. We argue that dual intracellular and surface locations may augment flexibility of cytokinin responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.