ArticleNature communications2020
Circadian clock mechanism driving mammalian photoperiodism.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
39 citing papers in PubMed, 74 citations in OpenAlex.
- Molecular characterization of circannual interval timing in the preoptic area and anteroventral periventricular nucleus in the Djungarian hamster (Phodopus sungorus).Journal of neuroendocrinology · 2026Article
- Photoperiodic regulation of Wnts in spermatogenesis of Brandt's vole (Lasiopodomys brandtii).Frontiers in zoology · 2026Article
- Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals.eLife · 2026Article
- Article
- Photoperiod effects on growth, lipid metabolism, and lipidomics analysis of tilapia.Frontiers in physiology · 2026Article
- Photoperiodic responsiveness in the DNA methylation and gene expression in the hypothalamus of ovariectomized and estradiol-treated ewes.BMC genomics · 2025Article
- Fine mapping genetic variants affecting birth weight in sheep: a GWAS of 3007 individuals using low-coverage whole genome sequencing.Journal of animal science and biotechnology · 2025Article
- Photo-refractoriness reflects bet-hedging strategies deployed in unpredictable environments in male Brandt's voles.Zoological letters · 2025Article
- Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons.Nature communications · 2025Article
- Transcriptome analysis of the hypothalamus and testes in Brandt's Vole: new insights into mechanisms of photoperiodic plasticity in postnatal testicular development.Functional & integrative genomics · 2025Article
- Dynamic Chromatin Accessibility and Transcriptional Regulation in the Eyes of Red Tilapia (Oreochromis sp.) in Response to Wintering Stress.Marine biotechnology (New York, N.Y.) · 2025Article
- Divergent Photoperiodic Responses in HypothalamicAnimals : an open access journal from MDPI · 2025Article
- BioClocks UK: driving robust cycles of discovery to impact.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Choosing which models best explain photoperiodic time measurement mechanisms in plants.Npj biological timing and sleep · 2025Review
- Tanycytes from a bird's eye view: gene expression profiling of the tanycytic region under different seasonal states in the Svalbard ptarmigan.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Melatonin inhibits circadian gene DEC1 and TLR2/MyD88/NF-κB signaling pathway to alleviate renal injury in type 2 diabetic mice.Acta diabetologica · 2024Article
- Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life.Cancer medicine · 2024Review
- Darwin and the biological rhythms.PNAS nexus · 2024Article
- Deep learning with a small dataset predicts chromatin remodelling contribution to winter dormancy of apple axillary buds.Tree physiology · 2024Article
- Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies support the universality of this so-called coincidence timer, but we lack understanding of the mechanisms involved. Here we show in mammals that long photoperiods induce the circadian transcription factor BMAL2, in the pars tuberalis of the pituitary, and triggers summer biology through the eyes absent/thyrotrophin (EYA3/TSH) pathway. Conversely, long-duration melatonin signals on short photoperiods induce circadian repressors including DEC1, suppressing BMAL2 and the EYA3/TSH pathway, triggering winter biology. These actions are associated with progressive genome-wide changes in chromatin state, elaborating the effect of the circadian coincidence timer. Hence, circadian clock-pituitary epigenetic pathway interactions form the basis of the mammalian coincidence timer mechanism. Our results constitute a blueprint for circadian-based seasonal timekeeping in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.