Evidence map›Paper›PMID 32855402›Full record

ArticleNature communications2020

TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis.

Sneha Damal Villivalam, Dongjoo You, Jinse Kim, Hee Woong Lim, Han Xiao, Pete-James H Zushin, Yasuo Oguri, Pouya Amin, Sona Kang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 60 citations in OpenAlex.

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  18. TET3-overexpressing macrophages promote endometriosis.The Journal of clinical investigation · 2024
    Article
  19. Science advances · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sneha Damal VillivalamNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA.
Dongjoo YouNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA.
Jinse KimNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA.
Hee Woong LimDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center Department of Pediatrics & Biomedical Informatics, University of Cincinnati, 3333 Burnet Ave. MLC 7024, Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0000-0001-8599-1808
Han XiaoNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA.
Pete-James H ZushinNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA.
Yasuo OguriUCSF Diabetes Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Cell and Tissue Biology, University of California, San Francisco, CA, 94143, USA.
Pouya AminNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA.
Sona KangNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, 94720, USA. kangs@berkeley.edu.ORCID http://orcid.org/0000-0002-9831-677X
University of California, Berkeley · USCincinnati Children's Hospital Medical Center · USUniversity of California, San Francisco · US

Funding

Epigenetic regulation of adipose development and remodelingR01DK116008 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Sona Kang · 2018 to 2026
$3.6M
NIDDK NIH HHS R01 DK116008
6 · The paper itself

Abstract

It has been suggested that beige fat thermogenesis is tightly controlled by epigenetic regulators that sense environmental cues such as temperature. Here, we report that subcutaneous adipose expression of the DNA demethylase TET1 is suppressed by cold and other stimulators of beige adipocyte thermogenesis. TET1 acts as an autonomous repressor of key thermogenic genes, including Ucp1 and Ppargc1a, in beige adipocytes. Adipose-selective Tet1 knockout mice generated by using Fabp4-Cre improves cold tolerance and increases energy expenditure and protects against diet-induced obesity and insulin resistance. Moreover, the suppressive role of TET1 in the thermogenic gene regulation of beige adipocytes is largely DNA demethylase-independent. Rather, TET1 coordinates with HDAC1 to mediate the epigenetic changes to suppress thermogenic gene transcription. Taken together, TET1 is a potent beige-selective epigenetic breaker of the thermogenic gene program. Our findings may lead to a therapeutic strategy to increase energy expenditure in obesity and related metabolic disorders.

Indexed as

Epigenesis, GeneticAdipocytes, BeigeAnimalsCalorimetry, IndirectCell LineCold TemperatureDiet, High-FatDisease Models, AnimalDNA-Binding ProteinsEnergy MetabolismGene Expression RegulationHEK293 CellsHumansInsulin ResistanceMaleMiceDNA-Binding ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseProto-Oncogene ProteinsTET1 protein, mouseUcp1 protein, mouseUncoupling Protein 1

Identifiers

PMID32855402
PMCPMC7453011
OpenAlexW3080194171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.