ArticleNature communications2020
Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- Duet between sugars and hormones: The molecular dialogue fine-tuning hypoxia acclimation in plants.Journal of integrative plant biology · 2026Review
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Research Progress on the Application of Plant Growth Regulators in the Rapid Propagation of Jujube by In Vitro Culture.Plants (Basel, Switzerland) · 2025Review
- Type-A and -C response regulator genes positively impact rice plant height and panicle architecture.Plant cell reports · 2025Article
- Non-Canonical Inter-Protein Interactions of Key Proteins Belonging to Cytokinin Signaling Pathways.Plants (Basel, Switzerland) · 2025Review
- Five unaddressed questions about cytokinin biosynthesis.Journal of experimental botany · 2025Review
- Structural basis of cytokinin transport by the Arabidopsis AZG2.Nature communications · 2025Article
- Dressed Up to the Nines: The Interplay of Phytohormones Signaling and Redox Metabolism During Plant Response to Drought.Plants (Basel, Switzerland) · 2025Review
- Multi-omics analysis of organ-specific hormone distribution and molecular regulatory mechanisms inFrontiers in plant science · 2025Article
- The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development.Plant physiology · 2024Article
- Primary multistep phosphorelay activation comprises both cytokinin and abiotic stress responses: insights from comparative analysis of Brassica type-A response regulators.Journal of experimental botany · 2024Article
- Spatially distributed cytokinins: Metabolism, signaling, and transport.Plant communications · 2024Review
- A pollen selection system links self and interspecific incompatibility in the Brassicaceae.Nature ecology & evolution · 2024Article
- Dissecting the Roles of the Cytokinin Signaling Network: The Case of De Novo Shoot Apical Meristem Formation.Biomolecules · 2024Review
- A novel toolbox to record CLE peptide signaling.Frontiers in plant science · 2024Article
- A Model of the Full-Length Cytokinin Receptor: New Insights and Prospects.International journal of molecular sciences · 2023Article
- Multi-Knock-a multi-targeted genome-scale CRISPR toolbox to overcome functional redundancy in plants.Nature plants · 2023Article
- The origin and early evolution of cytokinin signaling.Frontiers in plant science · 2023Review
- Cytokinin Regulates Energy Utilization in Botrytis cinerea.Microbiology spectrum · 2022Article
- Fourteen Stations of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site, while study of cytokinin transport pointed to the plasma membrane (PM)-mediated cytokinin signalling. Here, by detailed monitoring of subcellular localizations of the fluorescently labelled natural cytokinin probe and the receptor ARABIDOPSIS HISTIDINE KINASE 4 (CRE1/AHK4) fused to GFP reporter, we show that pools of the ER-located cytokinin receptors can enter the secretory pathway and reach the PM in cells of the root apical meristem, and the cell plate of dividing meristematic cells. Brefeldin A (BFA) experiments revealed vesicular recycling of the receptor and its accumulation in BFA compartments. We provide a revised view on cytokinin signalling and the possibility of multiple sites of perception at PM and ER.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.