Evidence map›Paper›PMID 32855300›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies.

Xinhai Chen, Miaomiao Shi, Xin Tong, Hwan Keun Kim, Lai-Xi Wang, Olaf Schneewind, Dominique Missiakas

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  3. Selective fluorination of Fc glycans enhances antibody-mediated effector functions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  12. Article
  13. Immunoglobulin G subclasses confer protection againstProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Review
  15. Review
  16. Review
  17. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinhai ChenHoward Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.ORCID 0000-0002-6771-6316
Miaomiao ShiHoward Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.
Xin TongDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
Hwan Keun KimHoward Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.
Lai-Xi WangDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.ORCID 0000-0003-4293-5819
Olaf SchneewindHoward Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439.
Dominique MissiakasHoward Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60439; dmissiak@bsd.uchicago.edu.ORCID 0000-0001-6482-9633

Funding

Vaccine Assembly from Surface Proteins of Staphylococcus AureusR01AI052474 · NIAID · UNIVERSITY OF CHICAGO · PI Dominique Missiakas · 2002 to 2026
$8.8M
Engineering monoclonal antibodies against Staphylococcus aureusR01AI148543 · NIAID · UNIVERSITY OF CHICAGO · PI Dominique Missiakas · 2020 to 2026
$5.5M
Glycoengineering of antibodies to modulate immune functionsR01AI155716 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI LAI-XI WANG · 2020 to 2026
$3.6M
NIAID NIH HHS R01 AI052474NIAID NIH HHS R01 AI148543NIAID NIH HHS R01 AI155716
6 · The paper itself

Abstract

Antibodies may bind to bacterial pathogens or their toxins to control infections, and their effector activity is mediated through the recruitment of complement component C1q or the engagement with Fcγ receptors (FcγRs). For bacterial pathogens that rely on a single toxin to cause disease, immunity correlates with toxin neutralization. Most other bacterial pathogens, including

Indexed as

AnimalsAntibodies, BacterialAntibodies, MonoclonalCell LineGlycosylationHEK293 CellsHumansMiceMice, Inbred BALB CPhagocytosisStaphylococcal InfectionsStaphylococcal Protein AStaphylococcus aureusAntibodies, BacterialAntibodies, MonoclonalStaphylococcal Protein AC1qFcγRglycosylationmonoclonal antibodyStaphylococcal protein A

Identifiers

PMID32855300
PMCPMC7502815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.