Evidence map›Paper›PMID 32855285›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2020

Deficits in verbal fluency in presymptomatic

Dorothée E Lulé, Hans-Peter Müller, Julia Finsel, Patrick Weydt, Antje Knehr, Ivar Winroth, Peter Andersen, Jochen Weishaupt, Ingo Uttner, Jan Kassubek and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Quantifying multimodal longitudinal brain changes in presymptomatic C9orf72 disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Composite grey matter fingerprints for genetic frontotemporal dementia.Journal of neurology, neurosurgery, and psychiatry · 2026
    Article
  11. Article
  12. Article
  13. New developments in imaging in ALS.Journal of neurology · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Dorothée E LuléDepartment of Neurology, Neuropsychology, Ulm University, Ulm, Germany dorothee.lule@uni-ulm.de.ORCID 0000-0001-5944-398X
Hans-Peter MüllerDepartment of Neurology, University of Ulm, Ulm, Germany.
Julia FinselDepartment of Neurology, University of Ulm, Ulm, Germany.
Patrick WeydtDepartment of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany.ORCID 0000-0003-2344-5662
Antje KnehrDepartment of Neurology, University of Ulm, Ulm, Germany.
Ivar WinrothClinical Science, Umeå University, Umeå, Sweden.
Peter AndersenNeurology, Umeå University, Umeå, Sweden.ORCID 0000-0003-0094-5429
Jochen WeishauptDepartment of Neurology, University of Ulm, Ulm, Germany.ORCID 0000-0002-3399-9784
Ingo UttnerDepartment of Neurology, University of Ulm, Ulm, Germany.
Jan KassubekDepartment of Neurology, University of Ulm, Ulm, Germany.ORCID 0000-0002-7106-9270
Albert C LudolphDepartment of Neurology, University of Ulm, Ulm, Germany.ORCID 0000-0002-5401-0904
Universität Ulm · DEClinical Science Institute · USNeurology, Inc · USUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA mutation in

methodsIn total, 36 non-symptomatic mutation carriers from ALS or FTD families were examined, including 21 subjects with

resultsDISCUSSION: Reduced verbal fluency performance seems to be a distinct clinical feature of

Indexed as

Asymptomatic DiseasesExecutive FunctionMemorySpatial ProcessingAdultAmyotrophic Lateral SclerosisBrainC9orf72 ProteinCase-Control StudiesDiffusion Tensor ImagingFemaleFrontotemporal DementiaHumansLanguageLanguage TestsLongitudinal StudiesC9orf72 ProteinSuperoxide Dismutase-1

Identifiers

PMID32855285
PMCPMC7569387
OpenAlexW3081506842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.