Evidence map›Paper›PMID 32855268›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

Genetics of Smoking Behaviors in American Indians.

Jeffrey A Henderson, Dedra S Buchwald, Barbara V Howard, Patricia Nez Henderson, Yafang Li, Rachel F Tyndale, Christopher I Amos, Olga Y Gorlova, Collaborative to Improve Native Cancer Outcomes (CINCO), a P50 Center for Population Health and Health Disparities program project sponsored by the National Cancer Institute

Open access · bronzeAbstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Identification of Sociodemographic, Clinical, and Genetic Factors to Aid Alaska Native and American Indian People to Successfully Quit Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jeffrey A HendersonBlack Hills Center for American Indian Health, Rapid City, South Dakota. jhenderson@bhcaih.org.ORCID 0000-0002-1873-6169
Dedra S BuchwaldElson S. Floyd College of Medicine, Washington State University, Seattle, Washington.
Barbara V HowardMedStar Health Research Institute, Hyattsville, Maryland.
Patricia Nez HendersonBlack Hills Center for American Indian Health, Rapid City, South Dakota.ORCID 0000-0002-1873-6169
Yafang LiBaylor College of Medicine, Institute for Clinical and Translational Research, Houston, Texas.
Rachel F TyndaleDepartment of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8540-7023
Christopher I AmosBaylor College of Medicine, Institute for Clinical and Translational Research, Houston, Texas.ORCID 0000-0002-8540-7023
Olga Y Gorlova
Collaborative to Improve Native Cancer Outcomes (CINCO), a P50 Center for Population Health and Health Disparities program project sponsored by the National Cancer Institute
Houston Institute for Clinical Research · USBlack Hills Center for American Indian Health · USCentre for Addiction and Mental Health · CAGeorgetown-Howard Universities Center for Clinical and Translational Science · USWashington State University Spokane · US

Funding

USING DIGITAL STORIES TO IMPROVE COLORECTAL CANCER SCREENING IN NATIVE AMERICANSP50CA148110 · NCI · UNIVERSITY OF WASHINGTON · PI GOLDBERG, JACK · 2010 to 2014
$9.7M
Training ProgramU54CA153498 · NCI · WASHINGTON STATE UNIVERSITY · PI BUCHWALD, DEDRA S, HENDERSON, JEFFREY A · 2010 to 2015
$4.1M
Lakota Center for Health Research-Administrative CoreS06GM123544 · NIGMS · BLACK HILLS CTR/AMERICAN INDIAN HEALTH · PI HENDERSON, JEFFREY A · 2017 to 2020
$2.3M
CIHR FDN-154294NCI NIH HHS P50 CA148110NCI NIH HHS U54 CA153498NIGMS NIH HHS S06 GM123544
6 · The paper itself

Abstract

backgroundThe smoking behavior of American Indians (AI) differs from that of non-Hispanic whites (NHW). Typically light smokers, cessation interventions in AIs are generally less effective. To develop more effective cessation programs for AIs, clinicians, researchers, and public health workers need a better understanding of the genetic factors involved in their smoking behavior. Our aim was to assess whether SNPs associated with smoking behavior in NHWs are also associated with smoking in AIs.

methodsWe collected questionnaire data on smoking behaviors and analyzed blood and saliva samples from two Tribal populations with dramatically different cultures and smoking prevalence, one in the Northern Plains (

resultsAmong 499 participants, we identified, in the Northern Plains sample only, a variant of the gamma-aminobutyric acid receptor subunit alpha-2 (

conclusionsThe contribution of many genes known to underlie smoking behaviors in NHWs may differ in AIs. IMPACT: Once validated, these variants could be useful in developing more effective cessation strategies.

Indexed as

AdultAgedAged, 80 and overAmerican Indian or Alaska NativeFemaleHumansMaleMiddle AgedSmokingSurveys and QuestionnairesYoung Adult

Identifiers

PMID32855268
PMCPMC8597394
OpenAlexW3080183763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.