Evidence map›Paper›PMID 32855266›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

Association of Body Mass Index with Fecal Microbial Diversity and Metabolites in the Northern Finland Birth Cohort.

Erikka Loftfield, Karl-Heinz Herzig, J Gregory Caporaso, Andriy Derkach, Yunhu Wan, Doratha A Byrd, Emily Vogtmann, Minna Männikkö, Ville Karhunen, Rob Knight and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  13. The gut microbiome: a core regulator of metabolism.The Journal of endocrinology · 2023
    Review
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  16. The Characteristics, Mechanisms and Therapeutics: Exploring the Role of Gut Microbiota in Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 5 countries.

Erikka Loftfield *Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland. erikka.loftfield@nih.gov.ORCID 0000-0002-3573-8748
Karl-Heinz Herzig *Research Unit of Biomedicine, Medical Research Center (MRC), University of Oulu, University Hospital, Oulu, Finland and Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
J Gregory CaporasoMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0002-8865-1670
Andriy DerkachBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0003-2178-8493
Yunhu WanBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Doratha A ByrdMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Emily VogtmannMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0003-1355-5593
Minna MännikköNorthern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-6857-6423
Ville KarhunenDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
Rob KnightDepartment of Pediatrics, University of California San Diego, San Diego, California.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer-WHO, Lyon, France.
Marjo-Riitta Järvelin *Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
Rashmi Sinha *Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
National Cancer Institute · USImperial College London · GBCentre international de recherche sur le cancer · FRNorthern Arizona University · USPoznan University of Medical Sciences · PLUniversity of Oulu · FIUniversity of San Diego · US

Funding

Lower Gastrointestinal Cancer StudiesZIACP010198 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SINHA, RASHMI · 2009 to 2025
$6.6M
Intramural NIH HHS Z99 CA999999World Health Organization 001
6 · The paper itself

Abstract

backgroundObesity is an established risk factor for multiple cancer types. Lower microbial richness has been linked to obesity, but human studies are inconsistent, and associations of early-life body mass index (BMI) with the fecal microbiome and metabolome are unknown.

methodsWe characterized the fecal microbiome (

resultsMicrobial richness, including the number of sequence variants (

conclusionsBMI is strongly related to fecal metabolite levels, and numerous associations between fecal microbial features and metabolite levels underscore the dynamic role of the gut microbiota in metabolism. IMPACT: Characterizing the associations between the fecal microbiome, the fecal metabolome, and BMI, both recent and early-life exposures, provides critical background information for future research on cancer prevention and etiology.

Indexed as

Body Mass IndexAdultCohort StudiesCross-Sectional StudiesFecesFemaleFinlandHumansMaleMetabolomicsMiddle Aged

Identifiers

PMID32855266
PMCPMC7642019
OpenAlexW3080954194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.