ArticleJournal of epidemiology and community health2020
How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK?
Article in Journal of epidemiology and community health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Mediators of socioeconomic differences in overweight and obesity among youth in Ireland and the UK (2011-2021): a systematic review.BMC public health · 2022Pooled it
- Individual and Interactive Effects of Adverse Childhood Experiences and Household Income on Adolescent Depression and Anxiety Symptoms.Research in nursing & health · 2026Article
- Integrating data science for the analysis of early years health inequalities: a Birmingham, UK case study.BMC medical informatics and decision making · 2026Article
- Associations between adverse childhood experiences and family health in adulthood: a national cross-sectional analysis.Archives of public health = Archives belges de sante publique · 2026Article
- Causal mediation approaches for understanding pathways to inequalities and policy entry points: examples from early years health and development.Journal of epidemiology and community health · 2026Article
- Adverse childhood experiences as a risk factor for depression-overweight comorbidity in adolescence and young adulthood.European journal of public health · 2025Article
- Effects of Adverse Childhood Experiences on Depression Among Chinese College Students: A Mediated Moderation Model of "Shift-and-Persist" Strategy and Perceived Everyday Discrimination.Behavioral sciences (Basel, Switzerland) · 2025Article
- Associations Among Childhood Household Income, Latent Classes of Early Adverse Childhood Experiences, and Adolescent Mental Health.Issues in mental health nursing · 2025Article
- Early life social conditions and adverse experiences are associated with childhood BMI and perceived overeating.Pediatric obesity · 2025Article
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- Indicators of resource scarcity differentially moderate the impact of threat exposure on psychopathology in a cross-sectional community sample of youth.Frontiers in child and adolescent psychiatry · 2025Article
- Psychosocial factors mediate social inequalities in health-related quality of life among children and adolescents.BMC public health · 2024Article
- Receipt of social services intervention in childhood, educational attainment and emergency hospital admissions: longitudinal analyses of national administrative health, social care, and education data in Wales, UK.BMC public health · 2024Article
- Mediating mechanisms of the relationship between exposure to deprivation and threat during childhood and adolescent psychopathology: evidence from the Millennium Cohort Study.European child & adolescent psychiatry · 2024Article
- Private screen access in early adolescence predicts subsequent academic and social impairment at the end of high school for boys and girls.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2024Article
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- The potential of intervening on childhood adversity to reduce socioeconomic inequities in body mass index and inflammation among Australian and UK children: A causal mediation analysis.Journal of epidemiology and community health · 2023Article
- Adverse Childhood Experiences and Adolescent Delinquency: A Theoretically Informed Investigation of Mediators during Middle Childhood.International journal of environmental research and public health · 2023Article
- Social inequalities in child development: the role of differential exposure and susceptibility to stressful family conditions.Journal of epidemiology and community health · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundBoth adverse childhood experiences (ACEs) and adverse childhood socioeconomic conditions (SECs) in early life are associated with poor outcomes across the life course. However, the complex interrelationships between childhood SECs and ACEs are unclear, as are the consequences for health outcomes beyond childhood. We therefore assessed the extent to which early-life ACEs mediate the relationship between SECs and socioemotional behavioural problems, cognitive disability and overweight/obesity in adolescence.
methodsWe used longitudinal data from the UK Millennium Cohort Study (MSC). Outcomes assessed at age 14 were socioemotional behavioural problems, cognitive disability and overweight/obesity. SECs at birth were measured by maternal education. Potentially mediating ACEs measured up to 5 years were verbal and physical maltreatment, parental drug use, domestic violence, parental divorce, maternal mental illness and high frequency of parental alcohol use. We used counterfactual mediation analysis to assess the extent to which ACEs mediate the association between SECs at birth and behavioural, cognitive and physical outcomes at age 14, estimating total (TE), natural direct and indirect effects, and mediated proportions.
resultsChildren with disadvantaged SECs were more likely to have socioemotional behavioural problems (relative risk (RR) 3.85, 95% CI 2.48 to 5.97), cognitive disability (RR 3.87, 95% CI 2.33 to 6.43) and overweight/obesity (RR 1.61, 95% CI 1.32 to 1.95), compared to those with more advantaged SECs. Overall, 18% of the TE of SECs on socioemotional behavioural problems was mediated through all ACEs investigated. For cognitive disability and overweight/obese, the proportions mediated were 13% and 19%, respectively.
conclusionACEs measured up to age 5 years in the MCS explained about one-sixth of inequalities in adolescents behavioural, cognitive and physical outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.