Evidence map›Paper›PMID 32855235›Full record

ArticleThe Journal of biological chemistry2020

Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition.

Sujayita Roy, Arun Kapoor, Fei Zhu, Rupkatha Mukhopadhyay, Ayan Kumar Ghosh, Hyun Lee, Jennifer Mazzone, Gary H Posner, Ravit Arav-Boger

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Roles of vimentin in health and disease.Genes & development · 2022
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sujayita RoyDepartment of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Arun KapoorDepartment of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Fei ZhuDepartment of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rupkatha MukhopadhyayDepartment of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ayan Kumar GhoshDepartment of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Hyun LeeCenter for Biomolecular Science and Department of Pharmaceutical Science, University of Illinois, Chicago, Illinois, USA.
Jennifer MazzoneDepartment of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland, USA.
Gary H PosnerDepartment of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland, USA.
Ravit Arav-BogerDepartment of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: rboger@mcw.edu.
Johns Hopkins University · USMedical College of Wisconsin · USUniversity of Illinois Chicago · US

Funding

Novel Artemisinin Derivatives for Cytomegalovirus TherapyR01AI093701 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BOGER, RAVIT · 2011 to 2015
$2.0M
NIAID NIH HHS R01 AI093701
6 · The paper itself

Abstract

The antimalarial agents artemisinins inhibit cytomegalovirus (CMV)

Indexed as

Antiviral AgentsArtemisininsArtesunateBinding SitesCalpainCell CycleCells, CulturedCytomegalovirusCytomegalovirus InfectionsDrug RepositioningHumansMass SpectrometryPhosphorylationProteasome Endopeptidase ComplexVimentinVirus ReplicationAntiviral AgentsArtemisininsArtesunateCalpainProteasome Endopeptidase ComplexVimentinwithaferin AWithanolidesartemisininscalpaincellular targetcytoskeletondrug discoveryHCMVherpesvirusthermal shiftvimentinvirus

Identifiers

PMID32855235
PMCPMC7606667
OpenAlexW3081704350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.