Evidence map›Paper›PMID 32855214›Full record

ArticlePostgraduate medical journal2021

Vitamin D status and outcomes for hospitalised older patients with COVID-19.

Vadir Baktash, Tom Hosack, Nishil Patel, Shital Shah, Pirabakaran Kandiah, Koenraad Van den Abbeele, Amit K J Mandal, Constantinos G Missouris

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In one paragraph

Article in Postgraduate medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  5. Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-analysis.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2022
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  14. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Vadir BaktashDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK.
Tom HosackDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK.
Nishil PatelDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK.
Shital ShahDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK.
Pirabakaran KandiahDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK.
Koenraad Van den AbbeeleDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK.
Amit K J MandalDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK.ORCID http://orcid.org/0000-0003-0986-5927
Constantinos G MissourisDepartment of Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, UK dinos.missouris@nhs.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOlder adults are more likely to be vitamin D deficient. The aim of the study was to determine whether these patients have worse outcomes with COVID-19.

methodsWe conducted a prospective cohort study between 1 March and 30 April 2020 to assess the importance of vitamin D deficiency in older patients with COVID-19. The cohort consisted of patients aged ≥65 years presenting with symptoms consistent with COVID-19 (n=105). All patients were tested for serum 25-hydroxyvitamin D (25(OH)D) levels during acute illness. Diagnosis of COVID-19 was confirmed via viral reverse transcriptase PCR swab or supporting radiological evidence. COVID-19-positive arm (n=70) was sub-divided into vitamin D-deficient (≤30 nmol/L) (n=39) and -replete groups (n=35). Subgroups were assessed for disease severity using biochemical, radiological and clinical markers. Primary outcome was in-hospital mortality. Secondary outcomes were laboratory features of cytokine storm, thoracic imaging changes and requirement of non-invasive ventilation (NIV).

resultsCOVID-19-positive arm demonstrated lower median serum 25(OH)D level of 27 nmol/L (IQR=20-47 nmol/L) compared with COVID-19-negative arm, with median level of 52 nmol/L (IQR=31.5-71.5 nmol/L) (p value=0.0008). Among patients with vitamin D deficiency, there was higher peak D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and higher incidence of NIV support and high dependency unit admission (30.77% vs 9.68%) (p=0.042). No increased mortality was observed between groups.

conclusionOlder adults with vitamin D deficiency and COVID-19 may demonstrate worse morbidity outcomes. Vitamin D status may be a useful prognosticator.

Indexed as

COVID-19Pneumonia, ViralVitamin D DeficiencyAgedBiomarkersFemaleFibrin Fibrinogen Degradation ProductsGeriatric AssessmentHospitalizationHospital MortalityHumansMaleOutcome Assessment, Health CarePredictive Value of TestsRadiography, ThoracicSARS-CoV-225-hydroxyvitamin DBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DVitamin Dcalcium & bonediabetes & endocrinologyGeneral medicine (see internal medicine)geriatric medicine

Identifiers

PMID32855214
PMCPMC7456620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.