Observational studyAJNR. American journal of neuroradiology2020
Characteristics of Large-Vessel Occlusion Associated with COVID-19 and Ischemic Stroke.
Observational study in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Association between SARS-CoV-2 and stroke: perspectives from a metaumbrella-review.BMC neurology · 2025Pooled it
- Special report of the RSNA COVID-19 task force: systematic review of outcomes associated with COVID-19 neuroimaging findings in hospitalized patients.The British journal of radiology · 2021Pooled it
- Neurological manifestations of patients infected with the SARS-CoV-2: a systematic review of the literature.Journal of neurology · 2021Pooled it
- Evaluation of the Wells score in predicting the incidence of stroke-associated pneumonia: the REMISE study.Frontiers in neurology · 2025Article
- Prevalence and 3-month follow-up of cerebrovascular MRI markers in hospitalized COVID-19 patients: the CORONIS study.Neuroradiology · 2024Observational
- Article
- Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke.Frontiers of medicine · 2023Review
- Stroke Risk Related to Coronavirus Disease-2019: What Have We Learned?Critical care nursing clinics of North America · 2023Review
- Acute Neurological Complications of Coronavirus Disease.Neuroimaging clinics of North America · 2023Review
- The impact of SARS-CoV-2 infection on the outcome of acute ischemic stroke-A retrospective cohort study.PloS one · 2023Article
- Cerebrovascular disease in COVID-19: a systematic review and meta-analysis.Le infezioni in medicina · 2023Review
- Cerebrovascular Complications of COVID-19 and COVID-19 Vaccination.Circulation research · 2022Review
- Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke.Journal of thrombosis and haemostasis : JTH · 2022Article
- Ischemic stroke in COVID-19 patients: Mechanisms, treatment, and outcomes in a consecutive Swiss Stroke Registry analysis.European journal of neurology · 2022Article
- Grace Under Pressure: Resiliency of Quality Monitoring of Stroke Care During the Covid-19 Pandemic in Mexico City.Frontiers in neurology · 2022Article
- Maintaining stroke care during the COVID-19 pandemic in lower- and middle-income countries: World Stroke Organization Position Statement endorsed by American Stroke Association and American Heart Association.International journal of stroke : official journal of the International Stroke Society · 2022Article
- [Ischemic stroke in coronavirus disease 2019].Der Internist · 2021Article
- Neurological Manifestations and Long-term Sequelae in Hospitalized Patients with COVID-19.Internal medicine (Tokyo, Japan) · 2021Article
- Neurointervention in the Era of COVID-19: Korean Nationwide Survey, Literature Review, and Recommendations.Neurointervention · 2021Review
- COVID-19 and ischemic stroke.European journal of neurology · 2021Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms and phenotype of ischemic stroke associated with coronavirus disease 2019 (COVID-19) remain uncertain. A retrospective study was conducted in patients with COVID-19 presenting with ischemic stroke from March 1 to May 25, 2020, and cases with large-vessel occlusion were identified. To provide baseline institutional stroke data within and outside the COVID-19 pandemic, all consecutive ischemic stroke and TIA admissions (COVID and non-COVID) to the hospital during a 10-week period from March 1 to May 10, 2020, were collected and compared with data from the same time period in 2019. Among 20 patients with COVID-19 and acute ischemic stroke, 15 (75%) had large-vessel occlusion. These patients were young (mean age, 46.5 years), male (93%), without major burden of traditional cardiovascular risk factors, and had a severe stroke presentation. Large-vessel occlusions were observed in multiple vessels (40%), uncommonly affected vessels, and atypical locations with a large thrombus burden. Systemic thrombosis separate from large-vessel occlusion was not uncommon (26%). At short-term follow-up, stroke etiology remained undetermined in 46% of patients and functional outcome was poor. The above findings raise the possibility of stroke related to mechanisms induced by the COVID-19 infection itself, including a hypercoagulable state and/or endothelial damage. In addition, they document the severe presentation and poor outcomes of large-vessel occlusion in COVID-19 ischemic stroke.
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