Evidence map›Paper›PMID 32854770›Full record

ArticleVeterinary research2020

NLRP3 played a role in Trichinella spiralis-triggered Th2 and regulatory T cells response.

Xuemin Jin, Xue Bai, Yong Yang, Jing Ding, Haining Shi, Baoquan Fu, Pascal Boireau, Mingyuan Liu, Xiaolei Liu

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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  12. Food and waterborne parasitology · 2022
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  14. Adjuvanticity of β -Glucan for Vaccine AgainstFrontiers in cell and developmental biology · 2021
    Article
  15. Nrf2 Participates in M2 Polarization byFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Xuemin JinKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Xue BaiKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Yong YangKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Jing DingKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Haining ShiMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Baoquan FuLanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Pascal BoireauJRU BIPAR, ANSES, École Nationale Vétérinaire d'Alfort, INRA, Université Paris-Est, Animal Health Laboratory, Maisons-Alfort, France.
Mingyuan LiuKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China. liumy36@163.com.
Xiaolei LiuKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China. liuxlei@163.com.ORCID http://orcid.org/0000-0003-2333-1358
Jilin University · CNÉcole Nationale Vétérinaire d'Alfort · FRLanzhou Veterinary Research Institute · CNMassachusetts General Hospital · US

Funding

Department of Science and Technology of Jilin Province (CN) 20180520042JHGuangdong Innovative and Enterpreneurial Research Team Program 2014ZT05S123National Key Research and Development Program of China 2017YFD0501300National Natural Science Foundation of China 31520103916National Natural Science Foundation of China 31872467
6 · The paper itself

Abstract

Trichinella spiralis maintains chronic infections within its host. Muscle larvae excretory-secretory products (MLES) typically induce parasite-specific immune responses such as the Th2 response and regulatory T cells (Tregs) by modulating dendritic cell (DC) phenotype via the recognition of pattern recognition receptors (PRRs), such as Nod-like receptors (NLRs). We aimed to investigate the role of NLRP3 in T. spiralis-triggered immune response. We found that larvae burden was increased in NLRP3

Indexed as

AnimalsFemaleLarvaMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinTh2 CellsT-Lymphocytes, RegulatoryTrichinella spiralisTrichinellosisNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousedendritic cellexcretory-secretory productsNLRP3Th2TregTrichinella spiralis

Identifiers

PMID32854770
PMCPMC7457311
OpenAlexW3082195874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.