ArticleBMC research notes2020
Hepatocyte paraffin 1 and arginase-1 are effective panel of markers in HBV-related HCC diagnosis in fine-needle aspiration specimens.
Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- HEPPAR1 and PIWIL2 as Panel Markers for Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Construction of HBV-HCC prognostic model and immune characteristics based on potential genes mining through protein interaction networks.Journal of cancer research and clinical oncology · 2023Article
- Roles of hypoxia-inducible factor in hepatocellular carcinoma under local ablation therapies.Frontiers in pharmacology · 2023Review
- Large-Scale Tissue Microarray Evaluation Corroborates High Specificity of High-Level Arginase-1 Immunostaining for Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2021Article
- Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma.Journal of veterinary science · 2021Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIn order to make successful treatment for HBV-related hepatocellular carcinoma, an early diagnosis is necessary. In this research we aimed to evaluate the IHC staining pattern of Hepatocyte paraffin 1 and arginase-1 and their performance in early diagnosis of HCC. The incidence of HepPar-1 and Arg-1 were evaluated by IHC in 121 patients (HBV, HCC, HBV + HCC) and 30 healthy subjects.
resultsArg-1 had significantly increased sensitivity in identification of HBV + HCC patients compared to HepPar-1 (P < 0.001). The sensitivity of arginase-1 is 96.3% whereas, the sensitivity of HepPar-1 is 72.7%. Arg-1 had higher specificity in identification of HBV + HCC patients compared to HepPar-1 (P < 0.05). With one positive marker, the sensitivity, the specificity and the positive predictive values and negative predictive value were 84.3%, 82.4%, 88.6% and 85.4% respectively. Also with one positive marker, the sensitivity and negative predictive value were significantly higher compared to the both 2 positive combinations. It was concluded that Arg-1 can improves the ability to detect HBV + HCC patients when compared with HepPar-1. When, both markers being positive, the specificity and PPVs of this combination were fairly higher. Concurrent use of these two proteins may be one of the best HCC detection patterns in needle specimens.
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Registered trials
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