ArticleJournal of foot and ankle research2020
Research on lower extremity health in patients with multiple sclerosis: a systematic scoping review.
Article in Journal of foot and ankle research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Virtual Reality-Based Therapy Improves Fatigue, Impact, and Quality of Life in Patients with Multiple Sclerosis. A Systematic Review with a Meta-Analysis.Sensors (Basel, Switzerland) · 2021Pooled it
- Interventional Feasibility Study Investigating Virtual Reality-Based Gait Assessment With Orthoses in People With Multiple Sclerosis: A Study Protocol.Clinical and translational science · 2026Article
- Assessment of Changes in Postural Stability and Load Distribution in Patients With Multiple Sclerosis After 12 Weeks of Self-Paced Exercises Programmed by a Physiotherapist: A Prospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Foot Health and Lower Extremity Function in People With Multiple Sclerosis: A Cross-Sectional Survey Study.Journal of foot and ankle research · 2025Article
- Muscle Quality of Knee Extensors Based on Several Types of Force in Multiple Sclerosis Patients with Varying Degrees of Disability.Medicina (Kaunas, Lithuania) · 2022Article
- Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment.PloS one · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) often affects ambulation and the function of the lower limbs. However, little is known about how much research has been conducted on lower extremity health in patients with MS.
objectiveTo analyse empirical studies and their evidence on lower extremity health in patients with MS, in order to identify the need for future studies in key areas.
methodsA systematic scoping review was conducted. A literature search of Medline (PubMed), CINAHL (EBSCO) and the Cochrane Library databases was performed. The search covered the period up to 15 January 2020 from the earliest records available. This led to the inclusion of 42 empirical articles. The data were analysed using content analysis and quantification techniques.
resultsThe research on lower extremity health focused primarily on two main areas: gait and lower extremity muscle strength. Lower extremity health was assessed using a variety of methods, most of which consisted of objective physical tests and gait analysis. Patients with MS had many problems with the health of their lower extremities, which manifested in walking difficulties, balance problems, muscle weaknesses and spasticity. In the feet, pes cavus, claw toes, oedema and altered foot sensation were common.
conclusionsMS affects lower limb and foot health, and these problems can affect patients' daily lives. However, the extent of these problems is poorly understood, partly due to the dearth of research on lower limb and foot health. Therefore, further research is warranted in order to better understand the impact of MS on foot and lower limb health in everyday life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.