ArticleThe American journal of psychiatry2020
Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation.
Article in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Common and disorder-specific aberrant activation during reward and loss processing in major depressive disorder and addiction: a meta-analysis of fMRI studies.Molecular psychiatry · 2026Pooled it
- Functional magnetic response imaging predictors of alcohol use disorder treatment outcome: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Pooled it
- Cue-Elicited Brain Activity and Treatment Outcomes in Substance Use Disorders: A Meta-Analysis.JAMA network open · 2025Pooled it
- Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study.Scientific reports · 2024Trial
- Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder.Psychopharmacology · 2023Trial
- Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder.Addiction biology · 2022Trial
- Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Alterations in glucose and insulin resistance following stress and alcohol cues predict alcohol craving in those with AUD and obesity: A preliminary study.Alcohol, clinical & experimental research · 2026 · on this mapArticle
- Exploring the association between sweet liking and treatment response to naltrexone in patients with alcohol use disorder.The international journal of neuropsychopharmacology · 2026Article
- Fronto-striatal neurometabolite signatures of impulsivity in early abstinence from methamphetamine.NeuroImage. Clinical · 2026Article
- Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner.Addiction neuroscience · 2025Article
- The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol.Addiction neuroscience · 2025Article
- The Neuropathology of Alcohol Use Disorder: Cellular Insights From Human Post-Mortem Studies.Journal of neurochemistry · 2025Review
- Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Network state dynamics underpin basal craving in a transdiagnostic population.Molecular psychiatry · 2025Article
- Investigating Therapeutic Targets for Alcohol Use Disorder: Pharmacological View of ClinicalTrials.gov Data.International journal of general medicine · 2025Review
- Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse.Current topics in behavioral neurosciences · 2025Review
- Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders.Current topics in behavioral neurosciences · 2025Review
- Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder.Addiction biology · 2024Article
- Re-evaluating our focus in addiction: emotional dysregulation is a critical driver of relapse to drug use.Translational psychiatry · 2024Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAlcohol use disorder (AUD) is associated with neuroadaptations in brain stress and reward circuits. It is not known whether such neuroadaptations are affected by number of days of alcohol abstinence and whether they influence heavy drinking during the early treatment phase. The authors used a novel functional MRI (fMRI) approach to assess brain responses during sustained exposure to standardized visual stimuli of stressful, alcohol cue, and neutral control images combined with prospective assessment of drinking outcomes during early outpatient treatment, in two related studies.
methodsIn study 1, 44 treatment-entering patients with AUD and 43 demographically matched healthy control subjects participated in the fMRI experiment to identify dysfunctional responses associated with chronic alcohol abuse. In study 2, 69 treatment-entering patients with AUD were assessed for whether fMRI responses at treatment initiation were influenced by alcohol abstinence and were prospectively predictive of early heavy drinking outcomes.
resultsRelative to control subjects, patients with AUD showed significant hyperreactivity in the ventromedial prefrontal cortex (vmPFC) in response to neutral images, but significant hypoactivation in the vmPFC and ventral striatum in response to stress images and to alcohol cues relative to response to neutral images. In study 2, this specific prefrontal-ventral striatal dysfunction was associated with fewer days of alcohol abstinence and also predicted greater number heavy drinking days during the subsequent 2 weeks of treatment engagement.
conclusionsNumber of days of alcohol abstinence at treatment initiation significantly affected functional disruption of the prefrontal-striatal responses to stress images and to alcohol cues in patients with AUD, and the severity of this disruption in turn predicted greater heavy drinking during early treatment. Treatments that target this functional prefrontal-striatal pathology could improve early treatment outcomes in AUD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.