Evidence map›Paper›PMID 32854533›Full record

Trial reportThe American journal of psychiatry2021

Treatment-Specific Associations Between Brain Activation and Symptom Reduction in OCD Following CBT: A Randomized fMRI Trial.

Luke J Norman, Kristin A Mannella, Huan Yang, Mike Angstadt, James L Abelson, Joseph A Himle, Kate D Fitzgerald, Stephan F Taylor

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  17. Defining brain-based OCD patient profiles using task-based fMRI and unsupervised machine learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Luke J NormanDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
Kristin A MannellaDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
Huan YangDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
Mike AngstadtDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
James L AbelsonDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
Joseph A HimleDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
Kate D FitzgeraldDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
Stephan F TaylorDepartment of Psychiatry, Medical School, University of Michigan, Ann Arbor (Norman, Mannella, Yang, Angstadt, Abelson, Himle, Fitzgerald, Taylor); Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Md. (Norman); Second Xiangya Hospital, Central South University, Changsha, China (Yang).
Central South University · CN

Funding

Neurocircuit mechanisms of OCD across the lifespanR01MH102242 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FITZGERALD, KATE DIMOND, TAYLOR, STEPHAN F · 2014 to 2018
$3.3M
NIMH NIH HHS R01 MH102242
6 · The paper itself

Abstract

objectiveThe authors sought to examine whether brain activity is associated with treatment response to cognitive-behavioral therapy (CBT) in adolescents and adults with obsessive-compulsive disorder (OCD), and whether any associations are treatment specific relative to an active control psychotherapy (stress management therapy; SMT).

methodsEighty-seven patients with OCD (age range 12-45 years; 57 female, 39 medicated) were randomly assigned to receive 12 weeks of CBT or SMT. Prior to treatment, functional MRI scans were conducted in patients performing an incentive flanker task, which probes brain activation to both cognitive control and reward processing. Voxelwise linear mixed-effects models examined whether baseline brain activation was differentially associated with change in scores on the Yale-Brown Obsessive Compulsive Scale (standard or Children's version) over the course of CBT or SMT treatment.

resultsWithin the CBT group, a better treatment response was significantly associated with greater pretreatment activation within the right temporal lobe and rostral anterior cingulate cortex during cognitive control and within the ventromedial prefrontal, orbitofrontal, lateral prefrontal, and amygdala regions during reward processing. In contrast, reduced pretreatment activation within a largely overlapping set of regions was significantly associated with a better treatment response to SMT.

conclusionsThe study findings demonstrate that associations between brain activation and treatment response were treatment specific to CBT relative to a control psychotherapy and that these associations were stable from adolescence to mature adulthood. Such treatment-specific associations are important for the development of biomarkers to personalize treatment in OCD.

Indexed as

Cognitive Behavioral TherapyAdolescentAdultBrainCarrier ProteinsChildFemaleFunctional NeuroimagingHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesStress, PsychologicalTreatment OutcomeYoung AdultCarrier ProteinsFrmpd1 protein, humanCognitive-Behavioral TherapyfMRIInhibitory ControlObsessive-Compulsive DisorderReward Processing

Identifiers

PMID32854533
PMCPMC8528223
OpenAlexW3082101597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.