ArticleThe American journal of psychiatry2020
The Sources of Parent-Child Transmission of Risk for Suicide Attempt and Deaths by Suicide in Swedish National Samples.
Article in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program.PLoS genetics · 2023Pooled it
- Suicidality phenotypes reflect both shared and distinct genetic factors.medRxiv : the preprint server for health sciences · 2026Article
- Sex differences in familial risk and genetic components of suicide attempts: a register-based cohort study in Sweden.BMJ mental health · 2026Article
- The association between the transition to parenthood and risk for nonfatal suicide attempt in a Swedish population-based sample.Psychological medicine · 2026Article
- Contrasting Risk Profiles for Suicide Attempt and Suicide Using Danish Registers and Genetic Data.JAMA psychiatry · 2026Article
- Genetic Overlap Between DSM-IV Major Depressive Disorder and Suicidal Behaviors: Evidence from Polygenic Risk Scores in Young Adult Twins.Behavior genetics · 2025Article
- The descent of agamemnon and the disquietude of job: The death of agency as the spur of suicide.Psychological review · 2025Review
- Work absence in parents of youth who self-harm.BMJ mental health · 2025Article
- Parental Mental Health and Suicidal Behavior as Predictors of Adolescent Suicidal Ideation and Attempts: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- The roles of adverse childhood experiences and genetic liability in risk for suicidal thoughts and behaviors: A factor analytic approach.Journal of affective disorders · 2025Article
- Article
- Psychological Risk Factors in the Transition from Suicidal Ideation to Suicidal Behavior in Young Adults.Healthcare (Basel, Switzerland) · 2024Article
- Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk.Journal of affective disorders · 2024Article
- Risk of suicidal behavior as a function of alcohol use disorder typologies: A Swedish population-based study.Addiction (Abingdon, England) · 2024Article
- Complex Intersections Between Adverse Childhood Experiences and Negative Life Events Impact the Phenome of Major Depression.Psychology research and behavior management · 2024Article
- Evolutionary conservation of putative suicidality-related risk genes that produce diminished motivation corrected by clozapine, lithium and antidepressants.Frontiers in psychiatry · 2024Article
- Using the Strategy of Genome-Wide Association Studies to Identify Genetic Markers of Suicidal Behavior: A Narrative Review.Consortium psychiatricum · 2024Review
- Children's cognitive performance and suicide risk through middle adulthood.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Life events and parent style for mental health in children: a cross-sectional study.Pediatric research · 2023Article
- Shared genetic and environmental etiology between substance use disorders and suicidal behavior.Psychological medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe authors aimed to clarify the sources of parent-child transmission for suicide attempt and death by suicide.
methodsThree sources of parent-child resemblance (genes plus rearing, genes only, and rearing only) were examined in parents and offspring from four family types from Swedish national samples: intact nuclear families, families with a not-lived-with biological father, families with a stepfather, and adoptees and their biological and adoptive parents. Parent-child resemblance was assessed primarily by tetrachoric correlation.
resultsFor suicide attempt to suicide attempt transmission, best-estimate tetrachoric correlations for genes plus rearing, genes only, and rearing only were 0.23 (95% CI=0.23, 0.24), 0.13 (95% CI=0.11, 0.15), and 0.14 (95% CI=0.11, 0.16), respectively. Suicide attempt was more strongly transmitted to male offspring compared with female offspring. Parental psychiatric disorders accounted for 40% of the genetic transmission but had no impact on rearing effects. For suicide death to suicide death transmission, best estimates of tetrachoric correlations for genes plus rearing, genes only, and rearing only were 0.16 (95% CI=0.15, 0.18), 0.07 (95% CI=0.02, 0.12), and -0.05 (95% CI=-0.17, 0.07), respectively. Although the suicide attempt-suicide death genetic correlation was high (0.84), the hypothesis that they reflect behaviors only differing in severity on the same continuum of genetic liability could be rejected.
conclusionsThe transmission of suicide attempt across generations is moderately strong and arises equally from genetic and rearing effects. Parental psychiatric illness explains almost half of the genetic transmission of suicide attempt but none of the rearing effect. Suicide death is modestly transmitted across generations, probably via genetic effects, although rearing may play a role. While suicide attempt and suicide death share a substantial proportion of their hereditary risk, they do not, from a genetic perspective, simply reflect milder and more severe forms of the same diathesis.
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