Evidence map›Paper›PMID 32854519›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in

Tsui-Ting Ching, Yen-Chieh Chen, Guang Li, Jianfeng Liu, X Z Shawn Xu, Ao-Lin Hsu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. The Controversial Roles of Areca Nut: Medicine or Toxin?International journal of molecular sciences · 2023
    Review
  4. Mechanisms of aging, age-associated diseases, and lifespan determination.Experimental biology and medicine (Maywood, N.J.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Tsui-Ting ChingInstitute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan.
Yen-Chieh ChenInstitute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan.
Guang LiLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4277-9844
Jianfeng LiuInternational Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
X Z Shawn XuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Ao-Lin HsuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2864-3134
National Yang Ming Chiao Tung University · TWEnvironmental Research Institute of Michigan · USHuazhong University of Science and Technology · CN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Functional aging of neuromuscular junctions in C. elegansR01AG051439 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HSU, AO-LIN ALLEN · 2015 to 2019
$1.9M
NIA NIH HHS R01 AG051439NIH HHS P40 OD010440
6 · The paper itself

Abstract

impact statementThe functional decline of motor activity is a common feature in almost all aging animals that leads to frailty, loss of independence, injury, and even death in the elderly population. Thus, understanding the molecular mechanism that drives the initial stage of this functional decline and developing strategies to increase human healthspan and even lifespan by targeting this process would be of great interests to the field. In this study, we found that by precisely targeting the motor neurons to potentiate its synaptic releases either genetically or pharmacologically, we can not only delay the functional aging at NMJs but also slow the rate of aging at the organismal level. Most importantly, we have demonstrated that a critical window of time, that is the early stage of NMJs functional decline, is required for the beneficial effects. A short-term treatment within this time period is sufficient to extend the animals' lifespan.

Indexed as

ExocytosisAnimalsArecolineCaenorhabditis elegansCaenorhabditis elegans ProteinsLongevityMotor NeuronsReceptors, MuscarinicSignal TransductionSynapsesSynaptic TransmissionArecolineCaenorhabditis elegans ProteinsReceptors, MuscarinicagingarecolineC. elegansLongevitymotor neuronneuromuscular junctionsynaptic exocytosistomosyn

Identifiers

PMID32854519
PMCPMC7787544
OpenAlexW3081737233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.