ArticleAnalytical chemistry2020
Macromolecular Orientation in Biological Tissues Using a Four-Polarization Method in FT-IR Imaging.
Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Probing 3D Molecular Orientation and Crystallization Behavior in PLLA/PEG Spherulites Using O-PTIR.Analytical chemistry · 2026Article
- Label-free mid-infrared dichroism-sensitive photoacoustic microscopy for histostructural analysis of engineered heart tissues.Light, science & applications · 2026Article
- Protein Analysis by FT-IR/ATR Spectroscopy.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Azimuth mapping of fibrous tissue in linear dichroism-sensitive photoacoustic microscopy.Photoacoustics · 2023Article
- 3D Orientation Imaging of Polymer Chains with Polarization-Controlled Coherent Raman Microscopy.Journal of the American Chemical Society · 2022Article
- Super-Resolved 3D Mapping of Molecular Orientation Using Vibrational Techniques.Journal of the American Chemical Society · 2022Article
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4 authors.
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Abstract
Fourier transform infrared spectroscopy has emerged as a powerful tool for tissue specimen investigation. Its nondestructive and label-free character enables direct determination of biochemical composition of samples. Furthermore, the introduction of polarization enriches this technique by the possibility of molecular orientation study apart from purely quantitative analysis. Most of the molecular orientation studies focused on polymer samples with a well-defined molecular axis. Here, a four-polarization approach for Herman's in-plane orientation function and azimuthal angle determination was applied to a human tissue sample investigation for the first time. Attention was focused on fibrous tissues rich in collagen because of their cylindrical shape and established amide bond vibrations. Despite the fact that the tissue specimen contains a variety of molecules, the presented results of molecular ordering and orientation agree with the theoretical prediction based on sample composition and vibration directions.
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