ArticleJournal of movement disorders2020
Emerging Concepts of Motor Reserve in Parkinson's Disease.
Article in Journal of movement disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Lifestyle medicine for neuroprotection: evidence and implementation in Asian contexts.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Parkinson's disease and the concept of resilience, cognitive, and motor reserve.Journal of Parkinson's disease · 2026Review
- Insole-Derived Plantar Pressure Variability Reveals Dual-Task Gait Differences in Early-Stage Parkinson's Disease.IEEE journal of translational engineering in health and medicine · 2026Article
- Behavioral markers of motor reserve: stability, lateralization, and consistency.Frontiers in aging neuroscience · 2026Article
- The Effects of Repetitive Transcranial Magnetic Stimulation on Gait, Motor Function, and Balance in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2025Review
- Physical fitness trends and factors influencing them in community-dwelling older adults: a longitudinal cohort study involving multiple tests.BMC geriatrics · 2025Article
- Is motor reserve associated with a rapid progression of Parkinson disease?Journal of Parkinson's disease · 2025Article
- Occipital hypoperfusion and motor reserve in Parkinson's disease: an early-phaseNPJ Parkinson's disease · 2024Article
- Article
- Structural underpinnings and long-term effects of resilience in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Review
- Article
- Clinical severity in Parkinson's disease is determined by decline in cortical compensation.Brain : a journal of neurology · 2024Article
- Lifestyle Modulators of Neuroplasticity in Parkinson's Disease: Evidence in Human Neuroimaging Studies.CNS & neurological disorders drug targets · 2024Review
- The greatest loss of unpleasant smells may be related to the risk of more severe PD symptoms.Frontiers in neurology · 2024Article
- Defining the concept of reserve in the motor domain: a systematic review.Frontiers in neuroscience · 2024Review
- Editorial: Cognitive, motor and brain reserves: bio-behavioral mechanisms, phenotypes, and prognostic value in ageing and neurodegeneration.Frontiers in psychology · 2024Article
- The association of motor reserve and clinical progression in Parkinson's disease.NeuroImage. Clinical · 2024Article
- Prevention of Falls in Parkinson's Disease: Guidelines and Gaps.Movement disorders clinical practice · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of cognitive reserve (CR) in Alzheimer's disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson's disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. The degree of motor deficits in PD is closely correlated to the degree of dopamine depletion; however, significant individual variations still exist. Therefore, we hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion. Since 2015, we have performed a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan. In this review, we summarized the results of these published studies. In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual's capacity to tolerate PD pathology, which can be maintained throughout disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.