Evidence map›Paper›PMID 32854402›Full record

ArticleMolecules (Basel, Switzerland)2020

Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.

Anna Czopek, Anna Partyka, Adam Bucki, Maciej Pawłowski, Marcin Kołaczkowski, Agata Siwek, Monika Głuch-Lutwin, Paulina Koczurkiewicz, Elżbieta Pękala, Anna Jaromin and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Antischistosomal activity of imidazolidine-2,4-dione derivatives.Antimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna CzopekDepartment of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.ORCID 0000-0002-1448-9826
Anna PartykaDepartment of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.ORCID 0000-0001-9606-5228
Adam BuckiDepartment of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.
Maciej PawłowskiDepartment of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.
Marcin KołaczkowskiDepartment of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.
Agata SiwekDepartment of Pharmacobiology, Jagiellonian University Collegium Medicum, 9 Medyczna Street, 30-688 Krakow, Poland.
Monika Głuch-LutwinDepartment of Pharmacobiology, Jagiellonian University Collegium Medicum, 9 Medyczna Street, 30-688 Krakow, Poland.
Paulina KoczurkiewiczDepartment of Pharmaceutical Biochemistry, Jagiellonian University Collegium Medicum, 9 Medyczna Street, 30-688 Krakow, Poland.
Elżbieta PękalaDepartment of Pharmaceutical Biochemistry, Jagiellonian University Collegium Medicum, 9 Medyczna Street, 30-688 Krakow, Poland.ORCID 0000-0002-1260-4253
Anna JarominDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, 14a Joliot-Curie, 50-383 Wroclaw, Poland.ORCID 0000-0002-7921-8007
Bożena TyliszczakFaculty of Materials Engineering and Physics, Cracow University of Technology, Institute of Materials Science, 24 Warszawska Street, 31-155 Krakow, Poland.ORCID 0000-0002-2761-6185
Anna WesołowskaDepartment of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.ORCID 0000-0003-2383-3278
Agnieszka ZagórskaDepartment of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.ORCID 0000-0003-2510-7237

Funding

Narodowe Centrum Nauki 2016/21/D/NZ7/01573Narodowe Centrum Nauki DEC-2012/07/B/NZ7/01173Uniwersytet Jagielloński Collegium Medicum N42/DBS/000020Uniwersytet Jagielloński Collegium Medicum N42/DBS/000104Uniwersytet Jagielloński Collegium Medicum N42/DBS/0001784
6 · The paper itself

Abstract

In this study, a series of compounds derived from 4-methoxy-1

Indexed as

Antipsychotic AgentsMolecular Docking SimulationAnimalsBehavior, AnimalDisease Models, AnimalHep G2 CellsHumansMicePhosphoric Diester HydrolasesReceptor, Serotonin, 5-HT1AReceptors, SerotoninSchizophreniaStructure-Activity RelationshipAntipsychotic AgentsHtr1a protein, mousePDE10A protein, humanPde10a protein, mousePhosphoric Diester HydrolasesReceptor, Serotonin, 5-HT1AReceptors, Serotoninserotonin 7 receptorantipsychotic activitybenzimidazole derivativesphosphodiesterase 10Aschizophrenia

Identifiers

PMID32854402
PMCPMC7504677

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.