Evidence map›Paper›PMID 32854391›Full record

ReviewVaccines2020

Current Clinical Trials Protocols and the Global Effort for Immunization against SARS-CoV-2.

Gabriel N A Rego, Mariana P Nucci, Arielly H Alves, Fernando A Oliveira, Luciana C Marti, Leopoldo P Nucci, Javier B Mamani, Lionel F Gamarra

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. A comparison between SARS-CoV-1 and SARS-CoV2: an update on current COVID-19 vaccines.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022
    Review
  5. Article
  6. Symmetrical drug-related intertriginous and flexural exanthema-like eruption after COVID-19 vaccine.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022
    Article
  7. Review
  8. Review
  9. Observational
  10. Review
  11. Systemic drug-related intertriginous and flexural exanthema like eruption after CoronaVac vaccine.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Gabriel N A RegoHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Mariana P NucciLIM44-Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-903, Brazil.
Arielly H AlvesHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.ORCID 0000-0003-3570-0827
Fernando A OliveiraHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.ORCID 0000-0002-7226-1694
Luciana C MartiHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.ORCID 0000-0002-3890-0827
Leopoldo P NucciCentro Universitário do Planalto Central UNICEPLAC, Brasília 72445-020, Brazil.
Javier B MamaniHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Lionel F GamarraHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Hospital Israelita Albert Einstein · BRCentro Universitário Central Paulista · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BR

Funding

CNPq 400856/2016-6INCT-FCx:FAPESP 2014/50983-3SisNANO2.0 442539/2019-3
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is the biggest health challenge of the 21st century, affecting millions of people globally. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has ignited an unprecedented effort from the scientific community in the development of new vaccines on different platforms due to the absence of a broad and effective treatment for COVID-19 or prevention strategy for SARS-CoV-2 dissemination. Based on 50 current studies selected from the main clinical trial databases, this systematic review summarizes the global race for vaccine development against COVID-19. For each study, the main intervention characteristics, the design used, and the local or global center partnerships created are highlighted. Most vaccine developments have taken place in Asia, using a viral vector method. Two purified inactivated SARS-CoV-2 vaccine candidates, an mRNA-based vaccine mRNA1273, and the chimpanzee adenoviral vaccine ChAdOx1 are currently in phase III clinical trials in the respective countries Brazil, the United Arab Emirates, the USA, and the United Kingdom. These vaccines are being developed based on a quickly formed network of collaboration.

Indexed as

COVID-19D)immunizationresearch and development (R&ampSARS-CoV-2vaccine

Identifiers

PMID32854391
PMCPMC7564421
OpenAlexW3080876592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.