Evidence map›Paper›PMID 32854230›Full record

ArticleMolecules (Basel, Switzerland)2020

FLIm and Raman Spectroscopy for Investigating Biochemical Changes of Bovine Pericardium upon Genipin Cross-Linking.

Tanveer Ahmed Shaik, Alba Alfonso-Garcia, Martin Richter, Florian Korinth, Christoph Krafft, Laura Marcu, Jürgen Popp

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tanveer Ahmed ShaikLeibniz Institute of Photonic Technology Jena e.V., Albert-Einstein-Str. 9, 07745 Jena, Germany.ORCID 0000-0002-3235-5709
Alba Alfonso-GarciaBiomedical Engineering Department, University of California Davis, Davis, CA 95616, USA.
Martin RichterInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany.
Florian KorinthLeibniz Institute of Photonic Technology Jena e.V., Albert-Einstein-Str. 9, 07745 Jena, Germany.
Christoph KrafftLeibniz Institute of Photonic Technology Jena e.V., Albert-Einstein-Str. 9, 07745 Jena, Germany.ORCID 0000-0003-1049-0560
Laura MarcuBiomedical Engineering Department, University of California Davis, Davis, CA 95616, USA.
Jürgen PoppLeibniz Institute of Photonic Technology Jena e.V., Albert-Einstein-Str. 9, 07745 Jena, Germany.ORCID 0000-0003-4257-593X

Funding

Bimodal platform for nondestructive analysis of engineered vascular biomaterialsR01HL121068 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GRIFFITHS, LEIGH GARETH, MARCU, LAURA · 2015 to 2018
$1.5M
Jena-Davis Alliance of Excellence in Biophotonics JEDISNHLBI NIH HHS R01 HL121068NIH HHS RO1HL1210689
6 · The paper itself

Abstract

Biomaterials used in tissue engineering and regenerative medicine applications benefit from longitudinal monitoring in a non-destructive manner. Label-free imaging based on fluorescence lifetime imaging (FLIm) and Raman spectroscopy were used to monitor the degree of genipin (GE) cross-linking of antigen-removed bovine pericardium (ARBP) at three incubation time points (0.5, 1.0, and 2.5 h). Fluorescence lifetime decreased and the emission spectrum redshifted compared to that of uncross-linked ARBP. The Raman signature of GE-ARBP was resonance-enhanced due to the GE cross-linker that generated new Raman bands at 1165, 1326, 1350, 1380, 1402, 1470, 1506, 1535, 1574, 1630, 1728, and 1741 cm

Indexed as

AnimalsCattleCross-Linking ReagentsExtracellular MatrixIridoidsOptical ImagingPericardiumSpectrum Analysis, RamanCross-Linking ReagentsgenipinIridoidscross-linkingFLImgenipinRaman spectroscopytissue engineering

Identifiers

PMID32854230
PMCPMC7503846

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.