Evidence map›Paper›PMID 32854196›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Hyperpolarized

Yurii Shepelytskyi, Francis T Hane, Vira Grynko, Tao Li, Ayman Hassan, Mitchell S Albert

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02638519 (Hyperpolarized Xenon-129 Functional Magnetic Resonance Imaging of Healthy Volunteers and Participants With Alzheimer's Disease), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02638519 early_phase1terminatednot on this map

Hyperpolarized Xenon-129 Functional Magnetic Resonance Imaging of Healthy Volunteers and Participants With Alzheimer's Disease

TypeinterventionalSponsorThunder Bay Regional Health Research InstituteRan2016 to 2022Enrolled51ConditionsAlzheimer DiseaseArmsTraditional Proton fMRI, Hyperpolarized Xenon-129 fMRI, Hyperpolarized Xenon-129, 1H-129Xe Dual-Tuned Quadrature Head Coil
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with HyperpolarizedMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  4. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Article
  6. The journal of physical chemistry letters · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. HyperpolarizedMagnetic resonance in medicine · 2022
    Review
  11. Article
  12. Article
  13. Enabling Clinical Technologies for HyperpolarizedAngewandte Chemie (International ed. in English) · 2021
    Review
  14. MeasuringMagnetic resonance in medicine · 2021
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yurii ShepelytskyiChemistry and Materials Science Program, Lakehead University, 955 Oliver Rd., Thunder Bay, ON P7B 5E1, Canada.ORCID 0000-0001-5526-7958
Francis T HaneThunder Bay Regional Health Research Institute, 980 Oliver Rd., Thunder Bay, ON P7B 5E1, Canada.ORCID 0000-0002-2738-584X
Vira GrynkoChemistry and Materials Science Program, Lakehead University, 955 Oliver Rd., Thunder Bay, ON P7B 5E1, Canada.ORCID 0000-0002-9580-0072
Tao LiChemistry Department, Lakehead University, 955 Oliver Rd., Thunder Bay, ON P7B 5E1, Canada.
Ayman HassanThunder Bay Regional Health Sciences Centre, 980 Oliver Rd., Thunder Bay, ON P7B 6V4, Canada.
Mitchell S AlbertThunder Bay Regional Health Research Institute, 980 Oliver Rd., Thunder Bay, ON P7B 5E1, Canada.
Thunder Bay Regional Research Institute · CALakehead University · CAThunder Bay Regional Health Sciences Centre · CA

Funding

Northern Ontario Academic Medicine Association A-18-05Ontario Research Foundation ORF RE 09 029
6 · The paper itself

Abstract

Perfusion measurements can provide vital information about the homeostasis of an organ and can therefore be used as biomarkers to diagnose a variety of cardiovascular, renal, and neurological diseases. Currently, the most common techniques to measure perfusion are

Indexed as

fMRIhemodynamic responsehyperpolarized 129Xehyperpolarized time-of-flight MRIperfusion imaging

Identifiers

PMID32854196
PMCPMC7554935
OpenAlexW3080911256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.