ArticlePloS one2020
Autism risk linked to prematurity is more accentuated in girls.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Identifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Risk factors for autism spectrum disorder among infants and children admitted in a neonatal intensive care unit.Dialogues in health · 2026Article
- Validation of the Modified Checklist for Autism in Toddlers (M-CHAT): A Replication Study of Diagnostic Accuracy.Journal of autism and developmental disorders · 2026Article
- Prematurity and autism: a dose-response relationship across gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Divergent representation and processing of task cues in sensory and prefrontal cortices of preterm-born mice.Nature communications · 2026Article
- Clinical and Sociodemographic Characteristics Associated with Access to Early Intervention Programs for Infants with Prodromes of Autism.Journal of clinical medicine · 2026Article
- Neonatal unit (NU) Infant Medical Trauma and the lifelong implications for children and their families.Frontiers in psychology · 2026Review
- Therapeutic Approach in Language and Cognitive Skills in Premature Twins with ASD: Case Report.Behavioral sciences (Basel, Switzerland) · 2025Article
- Risk Factors for Autism Spectrum Disorder in Individuals Born Preterm: A Systematic Review and Meta-Analysis of Population-Based Studies.Biological psychiatry global open science · 2025Article
- Identifying understudied correlations between autism & phenotypic attributes in a large family dataset.BMC psychology · 2025Article
- A Comprehensive Review on Plant-Based Medications and Chemical Approaches for Autism Spectrum Disorders (ASDs) Psychopharmacotherapy.Indian journal of microbiology · 2025Article
- Surviving prematurity: retrospective longitudinal study of multisystem consequences in preterm-born individuals from infancy to adolescence.BMC pediatrics · 2025Article
- Association of preterm birth and birth size status with neurodevelopmental and psychiatric disorders in spontaneous births.European child & adolescent psychiatry · 2025Article
- A Prediction Model of Autism Spectrum Diagnosis from Well-Baby Electronic Data Using Machine Learning.Children (Basel, Switzerland) · 2024Article
- Impact of sex, race, and social determinants of health on neonatal outcomes.Frontiers in pediatrics · 2024Review
- Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype.Journal of autism and developmental disorders · 2023Article
- A Comparison of the Clinical Presentation of Preterm Birth and Autism Spectrum Disorder: Commonalities and Distinctions in Children Under 3.Clinics in perinatology · 2023Review
- Prevention in Autism Spectrum Disorder: A Lifelong Focused Approach.Brain sciences · 2021Review
- Editorial: Personalized Precision Medicine in Autism Spectrum-Related Disorders.Frontiers in neurology · 2021Article
- Placental DNA methylation changes and the early prediction of autism in full-term newborns.PloS one · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrematurity has been identified as a risk factor for Autism Spectrum Disorder (ASD). The link between Autism Spectrum Disorder (ASD) and birth-week has not been strongly evidenced. We evaluated the correlation between the degree of prematurity and the incidence of autism in a cohort of 871 children born prematurely and followed from birth. The cohort was reduced to 416 premature infants born between 2011-2017 who were followed for 2-14 years, and analyzed according to birth week (degree of prematurity), and according to gender.
results43 children (10.3%) received a definite diagnosis of ASD. There was a significant correlation between birth week and the risk of ASD, with 22.6% of children diagnosed with ASD when born at 25 weeks, versus 6% of ASD diagnoses at 31 weeks of prematurity. For children born after 32 weeks, the incidence decreased to 8-12.5%. A strong link was found between earlier birth week and increased autism risk; the risk remained elevated during near-term prematurity in boys. A correlation between early birth week and an elevated risk for ASD was seen in all children, but accentuated in females, gradually decreasing as birth week progresses; in males the risk for ASD remains elevated for any birth week.
conclusionA statistically significant increase in rates of autism was found with each additional week of prematurity. Females drove this direct risk related to degree of prematurity, while males had an elevated risk throughout prematurity weeks, even at near-term. We recommend including ASD screening in follow up of infants born prematurely, at all levels of prematurity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.