Evidence map›Paper›PMID 32853984›Full record

ReviewEBioMedicine2020

CAR-NK cells: A promising cellular immunotherapy for cancer.

Guozhu Xie, Han Dong, Yong Liang, James Dongjoo Ham, Romee Rizwan, Jianzhu Chen

Abstract readReview
In one paragraph

Review in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 492 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
492citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

492 citing papers in PubMed, 1 synthesis or guideline pooled it.

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432 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guozhu XieKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Han DongDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA.
Yong LiangDivision of Hematologic Malignancies and Transplantation, Dana Farber Cancer Institute, Boston, MA 02115, USA.
James Dongjoo HamKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Romee RizwanDivision of Hematologic Malignancies and Transplantation, Dana Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: rizwan_romee@dfci.harvard.edu.
Jianzhu ChenKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: jchen@mit.edu.

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
Mucins and immune cell interactions in ovarian cancer pathogenesis & progressionR35CA197605 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRAMER, DANIEL WILLIAM · 2016 to 2022
$6.9M
Therapeutic modulation of the phagocytosis axis as a novel glioblastoma immunotherapyR01NS104315 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KIM, BETTY · 2018 to 2022
$1.7M
NCI NIH HHS P30 CA014051NCI NIH HHS R35 CA197605NINDS NIH HHS R01 NS104315
6 · The paper itself

Abstract

Natural Killer (NK) cells and CD8

Indexed as

Immunotherapy, AdoptiveAnimalsAntigens, NeoplasmBatch Cell Culture TechniquesCell- and Tissue-Based TherapyCell Culture TechniquesClinical Trials as TopicGenetic EngineeringHumansKiller Cells, NaturalNeoplasmsReceptors, Chimeric AntigenTreatment OutcomeAntigens, NeoplasmReceptors, Chimeric AntigenCancerChimeric antigen receptorImmunotherapyNK cells

Identifiers

PMID32853984
PMCPMC7452675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.