Evidence map›Paper›PMID 32853800›Full record

ArticleActa biomaterialia2020

Photoluminescent oxygen-release microspheres to image the oxygen release process in vivo.

Ya Guan, Hong Niu, Yu Dang, Ning Gao, Jianjun Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Targeted delivery of engineered adipose-derived stem cell secretome to promote cardiac repair after myocardial infarction.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ya GuanDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.
Hong NiuDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.
Yu DangDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.
Ning GaoDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.
Jianjun GuanDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA. Electronic address: jguan22@wustl.edu.
Washington University in St. Louis · US

Funding

Hydrogel encapsulation of a tissue repair protein to treat chronic woundsR01AG056919 · NIA · OHIO STATE UNIVERSITY · PI GUAN, JIANJUN, LI, HAICHANG · 2017 to 2021
$2.4M
Preservation and Vascularization of Cardiac Extracellular Matrix after Myocardial InfarctionR01HL138175 · NHLBI · WASHINGTON UNIVERSITY · PI GUAN, JIANJUN · 2019 to 2022
$1.8M
Stem Cell Oxygenation and Ischemic Tissue RegenerationR01HL138353 · NHLBI · WASHINGTON UNIVERSITY · PI GUAN, JIANJUN · 2017 to 2020
$1.5M
CONTROL OF CARDIAC FIBROSIS TO PREVENT CARDIAC FUNCTION DETERIORATIONR01EB022018 · NIBIB · WASHINGTON UNIVERSITY · PI GUAN, JIANJUN · 2016 to 2018
$1.1M
NHLBI NIH HHS R01 HL138175NHLBI NIH HHS R01 HL138353NIA NIH HHS R01 AG056919NIBIB NIH HHS R01 EB022018
6 · The paper itself

Abstract

Cell therapy is a promising strategy to treat ischemic diseases, but the efficacy is limited due to high rate of cell death under low oxygen environment of the ischemic tissues. Sustained release of oxygen to continuously oxygenate the transplanted cells may augment cell survival and improve therapeutic efficacy. We have shown previously that oxygen released from oxygen-release microspheres stimulated cell survival in ischemic tissue [1]. To understand how oxygen is released in vivo and duration of release, it is attractive to image the process of oxygen release. Herein, we have developed photoluminenscent oxygen-release microspheres where the in vivo oxygen release can be non-invasively and real-time monitored by an In Vivo Imaging System (IVIS). In the oxygen-release microspheres, a complex of polyvinylpyrrolidone, H

Indexed as

Mesenchymal Stem CellsOxygenCell SurvivalHydrogen PeroxideMicrospheresHydrogen PeroxideOxygenCell therapyIn vivo imagingIschemic vascular diseaseOxygen releasePhotoluminescence

Identifiers

PMID32853800
PMCPMC7530143
OpenAlexW3082762278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.